Tofacitinib suppliers

Tofacitinib

CAS:: 477600-75-2

MF:: C16H20N6O

MW:: 312.38

Use：: In November 2012, the US FDA approved tofacitinib (also referred to as CP-690550) for the treatment of adult patients with moderate to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to methotrexate. Tofacitinib is the first small molecule kinase inhibitor approved for the treatment of RA. Tofacitinib is an inhibitor of the four subtypes of Janus kinase (JAK): JAK1, JAK2, JAK3, and Tyk2. The JAKs are intracellular, nonreceptor tyrosine kinases that play important roles in the signal transduction pathway of many cytokines (e.g., interleukins 2, 4, 7, 9, 15, and 21) and are involved in the propagation of inflammation in RA. Tofacitinib acts by inhibiting the phosphorylation and activation of signal transducers and activators of transcription (STATs), thereby suppressing the production of inflammatory mediators in joint tissue. At the enzyme level, tofacitinib inhibits JAKs 1, 2, 3, and Tyk2 with IC50s of 3.2, 4.1, 1.6, and 34 nM, respectively. At the cellular level, tofacitinib inhibits the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50s of 406, 56, and 1377 nM, respectively.

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You can find Tofacitinib suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

ChemExpress

Tofacitinib
Remarks: Purity: >=98.O% | Package: 100g;1kg;10kg
TEL: +86-19370970350
CHINA Manufacturer

Henan Fengda Chemical Co., Ltd

Tofacitinib
Remarks: Purity: 99% | Package: 1KG;5USD|1000KG
TEL: 0371-86557731
CHINA Trader

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Tofacitinib.
Remarks: Purity: More Than 99% | Package: 1g
TEL: 010-87925929
CHINA Trader

Capot Chemical Co.,Ltd.

CP 690550
Remarks: Purity: 98% (Min,GC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
TEL: +86-（0）57185586718
CHINA Trader

Henan Tianfu Chemical Co.,Ltd.

tofacitinib
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
Remarks: Purity: 98% | Package: 1KG;100USD
TEL: 0371-86658258
CHINA Reagent

$100.00

CONIER CHEM AND PHARMA LIMITED

cp 690550
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

Tofacitinib
Remarks: Purity: 98% | Package: Package as requetsed
TEL: 021-+86-021-61551413
CHINA Trader

TargetMol Chemicals Inc.

Tofacitinib
Remarks: Purity: 99.71% | Package: 5mg;30USD|10mg;47USD|25mg;59USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

$30.00

$47.00

$59.00

Hefei Hangang Pharmaceutical Technology Co., Ltd.

Tofacitinib
Remarks: Purity: 0.99 | Package: 5KG;1KG
CHINA Trader