Atazanavir suppliers

Atazanavir

CAS:: 198904-31-3

MF:: C38H52N6O7

MW:: 704.86

Use：: Atazanavir is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease, an enzyme that is essential for the processing of Gag and Gag-Pol polyproteins into structural and enzymatic proteins required for viral replication. It has a similar pharmacophore motif to the other six widely marketed HIV protease inhibitors, most of which are based upon a hydroxyethylamine template. Uniquely, it possesses an aza-peptide motif but maintains many similar pharmacophore elements including lipophilic moieties that presumably bind to S2, S1, S′1 , and S′2 positions. Atazanavir is pseudo-symmetric about the central template, incorporating D-tert-Leucine at both termini. This compound is synthesized in about seven steps, with a key coupling of the chiral epoxide (derived from phenylalanine and imparting one chiral center) and N-tert-boc-N′-(4-[2-pyridyl]benzyl)hydrazine. Removal of both tert-Boc groups and double acylation with methoxycarbonyl-tert-Leucine provides the product. Another synthesis of atazanavir entails ten steps and utilizes α-(tert-bocamino) phenylpropanal as a chiral intermediate. It is a potent inhibitor of indinavir-resistant and saquinavir-resistant strains of HIV-1 (IC50=0.03–0.1 and 0.04–0.1 μM, respectively). In 300 patients who had failed previous treatment, atazanavir (400 mg once daily) was compared to lopinavir (400 mg twice daily) and ritonavir (100 mg); both arms additionally receiving two non-reverse transcriptase inhibitors. After 24 weeks, HIV RNA levels of ＜400 copies/mL were noted in 61% of patients receiving atazanavir and 81% of those taking lopinavir/ritonavir. After 96 weeks of therapy with atazanavir, HIV RNA copy levels were found to be ＜400 and ＜50 in 80 and 58% of patients, respectively. A study of the cross-resistance profile relative to other protease inhibitors using a panel of 551 clinical isolates (without prior atazanavir exposure but with cross-resistance to one or two other protease inhibitors; the majority had resistance to nelfinavir) showed that greater than 80% retained susceptibility to atazanavir. All of the resistant isolates from patients taking atazanavir had an I50 L substitution. The recommended dosage of atazanavir is 400 mg once daily. It has a mean half-life range of 7.9–6.5 h with about 60% bioavailability and moderate plasma protein binding (86% albumin and 89% alpha-1- acid glycoprotein (AAG)). Atazanavir was well tolerated in clinical studies and it displayed minimal lipid modulation when tested in combination with two non-reverse transcriptase inhibitors. Atazanavir had no effect on total cholesterol, low-density lipoprotein, and triglyceride levels when compared with other protease inhibitors that caused sustained elevations in these lipid levels.

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You can find Atazanavir suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Hebei Mujin Biotechnology Co.,Ltd

Atazanavir
Remarks: Purity: 99% | Package: 25KG
TEL: +86 13288715578
CHINA Service provider

￥0.00/25KG

Hebei Weibang Biotechnology Co., Ltd

Atazanavir
Remarks: Purity: 99%|Package: 1KG;0.00;USD|25KG;0.00;USD|1000KG;0.00;USD
CHINA Trader

￥0.00/1KG

￥0.00/25KG

￥0.00/1000KG

Henan Fengda Chemical Co., Ltd

Atazanavir
Remarks: Purity: 99% | Package: 1KG;5USD|1000KG;0.1USD
TEL: +86-371-86557731
CHINA Trader

￥5.00/1KG

￥0.10/1000KG

Capot Chemical Co.,Ltd.

BMS-232632
Remarks: Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
TEL: 571-85586718
CHINA Trader

Shanghai Daken Advanced Materials Co.,Ltd

Atazanavir
Remarks: Purity: 99% | Package: 100g ;1KG ;5KG 25KG
TEL: 371-+86-371-66670886
CHINA Trader

Henan Tianfu Chemical Co.,Ltd.

BMS-232632
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

Atazanavir
Remarks: Purity: 99% | Package: 1KG;1USD
TEL: 0371-86658258
CHINA Reagent

￥1.00/1KG

BOC Sciences

Atazanavir
Remarks: Purity: 0.98 | Package: 1g | CustNote: BOC Sciences also provides custom synthesis services for Atazanavir.
UNITED STATES Trader

CONIER CHEM AND PHARMA LIMITED

Atazanavir
Remarks: Purity: 99% | Package: 1kg
CHINA Trader

SIMAGCHEM CORP

Atazanavir
Remarks: Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
CHINA Trader