Product Name:	Atazanavir
Synonyms:	ATAZANAVIR, BISULFATE SALT;Atazanavir;(3S,8S, 9S, 12S)-2,5,6,13-Pentaazatetradecanedioic Acid;3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-dimethyl Ester;Methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[(4-pyridin-2-ylphenyl)methyl]amino]-1-phenylbutan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;(2S)-N-(3-{[(2S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoylamino][(4-(2-pyridyl)phenyl)methyl]amino}(1S,2S)-2-hydroxy-1-benzylpropyl)-2-(methoxycarbonylamino)-3,3-dimethylbutanamide;229975-97-7 (Sulfate 1:1);Aids057755
CAS:	198904-31-3
MF:	C38H52N6O7
MW:	704.87
EINECS:	1308068-626-2
Product Categories:	API;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Inhibitor;peptides
Mol File:	198904-31-3.mol

Chemical Properties	Crystalline Solid
Uses	Atazanavir is a novel azapeptide protease inhibitor (PI)
Uses	enzyme inhibitor
Uses	Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral.
Definition	ChEBI: A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV).
Uses	Atazanavir is an inhibitor of HIV-1 protease (EC50 = 2.6 nM). In isolated cells, it has additive to moderately synergistic antiviral effects when combined with other antiretroviral drugs. As a result, it is commonly used in vivo in combination therapy for HIV-1 infection. Atazanavir competitively inhibits UDP-gluronosyltransferase, which conjugates bilirubin for clearance, leading to hyperbilirubinemia in a significant portion of those receiving atazanavir therapy.

Atazanavir

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