캡타폴

한글명:캡타폴

카스 번호2425-06-1

상품명:CAPTAFOL

CBNumberCB9773422

분자식C10H9Cl4NO2S

포뮬러 무게349.06

MOL 파일2425-06-1.mol

동의어(한글)

캡타폴

켑타폴

2-(1,1,2,2-테트라클로로에틸설판일)-3a,4,7,7a-테트라하이드로아이소인돌-1,3-다이온

화학적 성질

녹는점	160-161°
끓는 점	365.7±52.0 °C(Predicted)
밀도	1.4682 (rough estimate)
증기압	1.1 x 10^-6 Pa (20 °C)
굴절률	1.6000 (estimate)
인화점	>100 °C
저장 조건	0-6°C
용해도	Chloroform (Sparingly), Dichloromethane (Very Slightly), Methanol (Slightly)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	-2.67±0.20(Predicted)
수용성	1.4mg l^-1(20°C)
색상	흰색에서 황백색까지
Merck	13,1777
IARC	2A (Vol. 53) 1991
EPA	Captafol (2425-06-1)

위험 및 안전 성명

위험품 표기	T,N
위험 카페고리 넘버	45-43-50/53
안전지침서	53-45-60-61
유엔번호(UN No.)	UN3077 9/PG 3
RTECS 번호	GW4900000
HS 번호	29305000
유해 물질 데이터	2425-06-1(Hazardous Substances Data)
독성	LD50 in rats, rabbits (mg/kg): 2500-6200 orally; 15400 dermally (Ben-Dyke)

그림문자(GHS)

캡타폴 화학적 특성, 용도, 생산

화학적 성질
Captafol is a white crystalline solid.
용도
Captafol is used to control a wide range of fungal diseases on many crops.
정의
ChEBI: A dicarboximide that captan in which the trichloromethyl group is replaced by a 1,1,2,2-tetrachloroethyl group. A broad-spectrum fungicide used to control diseases in fruit and potatoes, it is no longer approved for use in the European Community.
일반 설명
White crystalline solid with a slight, but pungent odor. Mp: 162°C. Practically insoluble in water. Only slightly soluble in organic solvents. Technical CAPTAFOL is a wettable light tan powder that is used as a fungicide. Inhaled dust irritates the respiratory tract. Irritates skin and damages eyes. Acute oral toxicity in humans is low. Not persistent in the environment (decomposes with a half-life of 11 days in the soil). Highly toxic to fish and other aquatic organisms.
반응 프로필
CAPTAFOL is non-flammable but, on heating, may decompose to generate toxic fumes, such as sulfur oxides, hydrogen sulfide, hydrochloric acid, and phosgene. Stable at room temperature when dry but readily hydrolysed, especially in an alkaline environment. CAPTAFOL and mixtures containing high concentrations of CAPTAFOL may react violently with alkali. Incompatible with acids, acid chlorides, acid anhydrides, and strong oxidizing agents. Sulfhydryl compounds such as glutathione and cysteine cause a rapid chemical decomposition.
위험도
Absorbed by skin. Probable carcinogen.
농업용
Fungicide: Captafol is a General Use Pesticide and used for the control of practically all forms of fungal diseases except powdery mildew. It is also used as a seed protectorant on cotton, rice and peanut crops. Not registered for use in the U.S. or in EU countries. There are 20 global suppliers.
상품명
CAPTATOL®; CAPTOFOL®; CRISFOLATAN®; DIFOLATAN®[C]; DIFOCAP®[C]; DIFOSAN®; FOLCID®; HAIPEN®; KENOFOL®; MERPAFOL®; ORTHO® 5865[C]; PILLARTAN®; SANSEAL®; SANSPOR®; SANTAR-SM®; SULFONIMIDE®; SULPHEIMIDE®
색상 색인 번호
Captafol is a pesticide, belonging to thiophthalimide group. Occupational contact dermatitis was reported in an agricultural worker who had multiple sensitizations
Safety Profile
Confirmed carcinogen with experimental carcinogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A fungicide. When heated to decomposition it emits very toxic fumes of Cl-, NO,, and SOx
잠재적 노출
Captafol is a thiophthalimide fungicide. Those engaged in the manufacture, formulation, and application of this fungicide. Captafol is not currently registered for use on field crops or stored produce in the United States.
Carcinogenicity
Captafol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting data on mechanisms of carcinogenesis.
환경귀착
The primary toxicity following captafol exposure probably occurs through a hypersensitivity mechanism. Most experiments suggest captafol to be DNA active.
신진 대사 경로
Captafol contains an unstable tetrachloroethylthio (sulfenyl) moiety that has been shown to undergo rapid hydrolytic and metabolic degradation to tetrahydrophthalimide (2). By analogy with captan, presumably the tetrachloroethylthio moiety can be transferred to the sulfur atoms of thiols such as cysteine and glutathone. Thus in the presence of thiols such as glutathione, captafol is probably cleaved at the N-S bond to form thiophosgene (3) and other gaseous products such as hydrogen sulfide, hydrogen chloride and carbonyl sulfide. Thiophosgene is rapidly hydrolysed by water. The tetrachloroethylthio group and thiophosgene are believed to be intermediates in the formation of thiazolidine-2- thione-6carboxylic acid (4) which is an addition product with cysteine. A thiazolidine derivative of glutathione is also formed (5). Biotransformation of captafol in mammals generates primarily thiophosgene (3) and tetrahydrophthalimide (2). Tetrahydrophthalimide (2) and various of its derivatives are excreted in the urine. There were no reports of 2-thiazolidinethione-4-carboxylic acid (4) in the urine.
운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN 2773 Phthalimide derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
비 호환성
Reacts violently with bases, causing fire and explosion hazard. Not compatible with strong acids or acid vapor, oxidizers. Strong alkaline conditions contribute to instability. Attacks some metals.
폐기물 처리
Hydrolysis.

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