Triflusal

한글명:Triflusal

카스 번호322-79-2

상품명:Triflusal

CBNumberCB9446472

분자식C10H7F3O4

포뮬러 무게248.16

MOL 파일322-79-2.mol

화학적 성질

녹는점	120-122° (upon slow heating); 110-112° (upon quick heating)
끓는 점	316.0±42.0 °C(Predicted)
밀도	1.433±0.06 g/cm3(Predicted)
저장 조건	Sealed in dry,2-8°C
용해도	DMSO: >30mg/mL
산도 계수 (pKa)	2.97±0.10(Predicted)
물리적 상태	가루
색상	흰색에서 황백색까지
최대 파장(λmax)	297nm(H2O)(lit.)
Merck	14,9688
CAS 데이터베이스	322-79-2(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

22-36/37/38-43

안전지침서

26-36/37

WGK 독일

RTECS 번호

GP4250000

HS 번호

2918.29.7500

NFPA 704:

	0
2		0

그림문자(GHS)

Triflusal 화학적 특성, 용도, 생산

화학적 성질
White to Off-White Solid
용도
An analog of Aspirin; inhibits platelet aggregation. Antithrombotic.
Mechanism of action
2-hydroxy-4-trifluoromethylbenzoic acid (HTB), the deacetylated metabolite of triflusal, retains significant antiplatelet activity. Triflusal is rapidly absorbed and metabolized. The area under the concentration–time curve for triflusal is 20.26 mg/L/hour after a 900-mg dose, whereas that for HTB is 42.27 mg/L/hour. Much of the pharmacokinetic data for triflusal activity is associated with HTB. The inhibition of COX, as measured by reduced production of thromboxane B2, is 25% after 2 hours and 85% after 7 days with triflusal, whereas the effects of aspirin on thromboxane B2 is more than 90% reduction after 2 hours and is maintained at this level after 7 days. It would appear that the presence of a 4-trifluoromethyl group also greatly enhances triflusal's ability to inhibit the activation of nuclear factor κB, which in turn regulates the expression of the mRNA of vascular cell adhesion molecule-1 needed for platelet aggregation. In addition, triflusal increases nitric oxide synthesis in neutrophils, which results in an increased vasodilatory potential. Finally, an additional site of action for triflusal/HTB is the inhibition of cAMP phosphodiesterase, leading to increased levels of cAMP. Elevated cAMP levels decrease platelet aggregation through decreased mobilization of calcium. Aspirin and salicylic acid do not significantly increase cAMP levels.
Clinical Use
Triflusal (2-acetoxy-4-trifluoromethyl benzoic acid) is an antiplatelet drug that despite its structural similarity to aspirin exhibits quite different pharmacological and pharmacokinetic properties.

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