초산프탈산셀룰로오즈

한글명:초산프탈산셀룰로오즈

카스 번호9004-38-0

상품명:Cellulose acetate phthalate

CBNumberCB9396579

분자식C116H116O64

포뮬러 무게2534.12

MOL 파일Mol file

동의어(한글)

초산프탈산셀룰로오즈

셀룰로오스아세테이트프탈레이트

화학적 성질

용해도	물에 거의 녹지 않으며, 아세톤에 잘 녹고, 디에틸렌 글리콜에 녹고, 에탄올(96%)과 염화메틸렌에는 거의 녹지 않습니다. 알칼리 수산화물의 묽은 용액에 용해됩니다.
EPA	Cellulose, acetate hydrogen 1,2-benzenedicarboxylate (9004-38-0)

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	20/21/22-36/37/38
안전지침서	24/25-36-26
WGK 독일	3
RTECS 번호	FJ5692000
HS 번호	39129010

그림문자(GHS)

초산프탈산셀룰로오즈 MSDS

초산프탈산셀룰로오즈 화학적 특성, 용도, 생산

화학적 성질
Cellulose acetate phthalate is a hygroscopic, white to off-white, freeflowing powder, granule, or flake. It is tasteless and odorless, or might have a slight odor of acetic acid.
용도
Enteric coating in pharmaceutical products.
생산 방법
Cellulose acetate phthalate is produced by reacting the partial acetate ester of cellulose with phthalic anhydride in the presence of a tertiary organic base such as pyridine, or a strong acid such as sulfuric acid.
Pharmaceutical Applications
Cellulose acetate phthalate (CAP) is used as an enteric film coating material, or as a matrix binder for tablets and capsules. Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment.
Cellulose acetate phthalate is commonly applied to solid-dosage forms either by coating from organic or aqueous solvent systems, or by direct compression. Concentrations generally used are 0.5–9.0% of the core weight. The addition of plasticizers improves the water resistance of this coating material, and formulations using such plasticizers are more effective than when cellulose acetate phthalate is used alone.
Cellulose acetate phthalate is compatible with many plasticizers, including acetylated monoglyceride; butyl phthalybutyl glycolate; dibutyl tartrate; diethyl phthalate; dimethyl phthalate; ethyl phthalylethyl glycolate; glycerin; propylene glycol; triacetin; triacetin citrate; and tripropionin. It is also used in combination with other coating agents such as ethyl cellulose, in drug controlledrelease preparations.
Therapeutically, cellulose acetate phthalate has recently been reported to exhibit experimental microbicidal activity against sexually transmitted disease pathogens, such as the HIV-1 retrovirus.
Safety Profile
An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety
Cellulose acetate phthalate is widely used in oral pharmaceutical products and is generally regarded as a nontoxic material, free of adverse effects. Results of long-term feeding in rats and dogs have indicated a low oral toxicity. Rats survived daily feedings of up to 30% in the diet for up to 1 year without showing a depression in growth. Dogs fed 16 g daily in the diet for 1 year remained normal.
저장
Slow hydrolysis of cellulose acetate phthalate will occur under prolonged adverse conditions such as high temperatures and high humidity, with a resultant increase in free acid content, viscosity, and odor of acetic acid. However, cellulose acetate phthalate is stable if stored in a well-closed container in a cool, dry place.
비 호환성
Cellulose acetate phthalate is incompatible with ferrous sulfate, ferric chloride, silver nitrate, sodium citrate, aluminum sulfate, calcium chloride, mercuric chloride, barium nitrate, basic lead acetate, and strong oxidizing agents such as strong alkalis and acids.
Regulatory Status
Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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