Cefmetazole

한글명:Cefmetazole

카스 번호56796-20-4

상품명:Cefmetazole

CBNumberCB9231320

분자식C15H17N7O5S3

포뮬러 무게471.53

MOL 파일56796-20-4.mol

화학적 성질

녹는점	163-165?C
밀도	1.4380 (rough estimate)
굴절률	1.7400 (estimate)
저장 조건	2-8°C
용해도	메탄올(약간 가열)에 용해됨
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	2.65±0.50(Predicted)
색상	하얀색
수용성	물에 용해됨
CAS 데이터베이스	56796-20-4(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38-42/43

안전지침서

26-36

WGK 독일

RTECS 번호

XI0372200

HS 번호

2941906000

NFPA 704:

	0
2		0

그림문자(GHS)

Cefmetazole 화학적 특성, 용도, 생산

개요
Cefmetazole is a cephamycin with a nonaromatic side chain at C-7. In addition to a fairly characteristic second-generation cephalosporin antimicrobial spectrum, it possess fairly significant anti-antiaerobic activity. The ejection of its C-3 side chain leads to alcohol intolerance of the disulfuram type and prolonged clotting times.
일반 설명
Cefmetazole was synthesized by Sankyo Co. in 1976starting with a biosynthetic cephamycin. It shows excellent activity against Serratia and Proteus, against which cefazolin is not active, and it has stronger activity than cefoxitin, another derivative of cephamycin. Cefmetazole is active against anaerobes and resistant to β-lactamase, but it is not active against Pseudomonas aeruginosa.
화학적 성질
White Solid
용도
Semi-synthetic antibiotic derived from Cephamycin. Antibacterial.
정의
ChEBI: A cephalosporin antibiotic containg an N1-methyltetrazol-5-ylthiomethyl side-chain at C-3 of the parent cephem bicyclic structure.
Antimicrobial activity
It is active against Pr. mirabilis, Pr. vulgaris, Morganella morganii, Yersinia spp.and most anaerobes. S. marcescens is moderately susceptible, but Ps. aeruginosa and E. faecalis are resistant. It is active against Mycobacterium fortuitum and some strains of M. chelonei. It is resistant to a wide range of β-lactamases.
The serum concentration at the end of a 1 g intravenous infusion is around 77 mg/L. Plasma protein binding is 68%. It is principally excreted in the urine with a plasma half-life of c. 1.3 h; 70% is recovered over the first 6 h. In patients whose creatinine clearance is less than 10 mL/min, plasma levels are elevated and the plasma half-life is increased to around 15 h.
Side effects associated with the methylthiotetrazole group at position C-3 have been reported. Uses are similar to those of cefoxitin, but it is not widely available.

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