다이크로토포스(디크로토포스)

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H410：장기적 영향에 의해 수생생물에 매우 유독함

• 예방조치문구

  P260：분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.

  P262：눈, 피부, 의복에 묻지 않도록 하시오.

  P273：환경으로 배출하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

다이크로토포스(디크로토포스) 화학적 특성, 용도, 생산

• 개요

  It is a yellowish liquid, bp 130 ?C/0.1 mmHg, vp 9.3 mPa (20 ?C). It ismiscible with water and most organic solvents except kerosene. Log Kow = ?0.5. Dicrotophos is rather stable to heat and slowly hydrolyzed in acidic media and more rapidly in alkaline media; DT₅₀ (20 ?C) at pH 5, 7, and 9 are 88, 72, and 28 d, respectively.

• 화학적 성질

  Dicrotophos is an amber liquid with a mild ester odor.

• 용도

  Dicrotophos is used to control sucking, chewing and boring insects and mites in a wide range of crops. It is also used as an animal ectoparasiticide.

• 제조 방법

  Dicrotophos is synthesized by the Perkow reaction from trimethyl phosphite and N,N-dimethyl-α- chloroacetoacetamide, consisting mainly of the (E)-form.

• 일반 설명

  A yellow to brown liquid with a mild ester odor. Used to control sucking, boring, and chewing pests on rice, cotton, coffee, apples, and other crops. Effective on ornamentals, trees, and shrubs for aphids, leaf hoppers, and scale insects.

• 공기와 물의 반응

  Water soluble.

• 반응 프로필

  Organophosphates, such as DICROTOPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. DICROTOPHOS is incompatible with the following: Metals [Note: Corrosive to cast iron, mild steel, brass & stainless steel.] .

• 건강위험

  DICROTOPHOS is extremely toxic. Probable human oral lethal dose is 5 to 50 mg/kg, 7 drops to one teaspoonful for a 70 kg (150 lb.) person. Closely related in toxicity to azodrin.

• 화재위험

  (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) DICROTOPHOS may burn but does not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Rapidly hydrolyzes in acid or alkali. Keep away from heat and open flame.

• 농업용

  Insecticide, Acaricide: EPA restricted Use Pesticide (RUP). Not approved for use in EU countries. Dicrotophos was introduced in 1956 as a contact systemic pesticide with a wide range of applications. Today, dicrotophos is currently used mainly as an insecticide for apples and other fruit crops, and for cotton pests, mostly in the Mississippi Valley. It is acutely toxic to birds, especially those that follow their migratory corridors and feed in the farmlands that have been treated with this pesticide. Internationally, dicrotophos is used on rice, coffee and citrus. One of the major degradates of dicrotophos is monocrotophos. All uses of monocrotophos have been voluntarily cancelled in the United States due to its extreme toxicity to humans and wildlife

• 상품명

  BIDIRL®; BIDRIN®; BIDRIN-R®[C]; BIDRIN®[C]; C-709®; C-709®; CARBICRIN®; CARBICRON®; CARBOMICRON®; CIBA 709®; DIAPADRIN®; DICRON®; DIDRIN®; EKTAFOS®; EKTOFOS®;

• Safety Profile

  Poison by ingestion, inhalation, skin contact, subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. Used to control the coffee borer and certain economically important pests of cotton. When heated to decomposition it emits very toxic fumes of NOx and POx. See also ESTERS.

• 잠재적 노출

  A potential danger to those involved in the manufacture, formulation and application of this organophosphate. Used to control the coffee borer and certain economically important pests of cotton

• Carcinogenicity

  When rats were fed dicrotophos in their diets at concentrations of 0, 1, 10, or 100 ppm for 2 years, there were no detectable effects at the 1 ppm concentration . Plasma cholinesterase was inhibited at 1 ppm . At 10 and 100 ppm, decreased body weights and reduced cholinesterase (erythrocyte, plasma, and brain not specified) activities occurred. Dogs given dicrotophos in their diets at 0, 0.16, 1.6, or 16 ppm for 2 years showed some instances of slightly excessive salivation . At 16 ppm, both plasma and RBC cholinesterase activity was decreased.

• 환경귀착

  Soil. The dimethylamino group is converted to an N-oxide then to -CH2OH and aldehyde groups which further degrade via demethylation and hydrolysis (Hartley and Kidd, 1987). Dicrotophos is rapidly degraded under aerobic and anaerobic conditions forming N,N-dimethylacetoacetamide and 3-hydroxy-N,N-dimethylbutyramide as the major metabolites. Other metabolites included carbon dioxide and unextractable residues. The half-life of dicrotophos in a Hanford sandy loam soil was 3 days (Lee et al., 1989).Biological. Identified metabolites of dieldrin from solution cultures containing Pseudomonas sp. in soils include aldrin and dihydroxydihydroaldrin. Other unidentified byproducts included a ketone, an aldehyde and an acid (Matsumura et al., 1968; Kearney and Kaufman, 1976). A pure culture of the marine alga, namely Dunaliella sp., degraded dieldrin to photodieldrin and an unknown metabolite at yields of 8.5 and 3.2%, respectively.
  Chemical/Physical. Dicrotophos emits toxic fumes of phosphorus and nitrogen oxides when heated to decomposition (Sax and Lewis, 1987; Lewis, 1990).
  Dicrotophos is hydrolyzed in sodium hydroxide solutions forming dimethylamine. The hydrolysis half-lives at 38°C and pH values of 1.1 and 9.1 are 100 and 50 days, respectively (Sittig, 1985). Lee et al. (1989) reported that the hydrolysis half-lives of di

• 신진 대사 경로

  The metabolic fate of dicrotophos mirrors very closely that of its close congener, monocrotophos. Technical dicrotophos contains 82% of the E-isomer and 6% of the Z-isomer, the balance being various impurities. Most studies on the metabolic fate of this compound have used a purified material containing >99% E-isomer. Dicrotophos is a systemic vinyl phosphate insecticide with a high water solubility and low log Kow.
  The main routes of metabolic degradation are demethylation to des- O-methyldicrotophos and hydrolysis to dimethyl phosphate and N,N-dimethylacetoacetamide. In animals and plants, hydroxylation of the N-methyl group followed by N-demethylation are also important from a toxicological point of view, since these metabolic steps yield highly active idubitors of acetylcholinesterase. In the case of dicrotophos, N-demethylation affords monocrotophos as one of the products of metabolism.

• 신진 대사

  The main degradation routes are O-demethylation to des-O-methyldicrotophos and hydrolysis to dimethyl phosphate and N,N-dimethylacetoacetamide. Oxidative Ndemethylation also occurs.

• 운송 방법

  UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• 비 호환성

  Attacks some metals: Corrosive to cast iron, mild steel; brass, and stainless steel l304. Decomposes after prolonged storage, but is stable when stored in glass or polyethylene containers with temperatures to 40C. Contact with oxidizers may cause the release of phosphorous oxides. Contact with strong reducing agents, such as hydrides, may cause the formation of flammable and toxic phosphine gas

• 폐기물 처리

  Dicrotophos decomposes after 7 days @ 90C and 31 days @ 75°C. Hydrolysis is 50% complete in aqueous solutions @ 38C after 50 days at pH 9.1 (100 days are required at pH 1.1). Alkaline hydrolysis (NaOH) yields (CH3)2NH. Incineration is also recommended as a disposal method. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

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