Fmoc-Lys(Ddiv)-OH

한글명:Fmoc-Lys(Ddiv)-OH

카스 번호204777-78-6

상품명:Fmoc-Lys(Ddiv)-OH

CBNumberCB9168561

분자식C34H42N2O6

포뮬러 무게574.71

MOL 파일204777-78-6.mol

화학적 성질

끓는 점	765.6±60.0 °C(Predicted)
밀도	1.183±0.06 g/cm3(Predicted)
저장 조건	2-8°C
용해도	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
산도 계수 (pKa)	3.88±0.21(Predicted)
물리적 상태	가루
색상	하얀색
InChIKey	PYCBVLUBTMHNPW-MHZLTWQESA-N
SMILES	C(O)(=O)[C@H](CCCCN/C(=C1/C(=O)CC(C)(C)CC/1=O)/CC(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

위험 및 안전 성명

WGK 독일	3
F 고인화성물질	10-21
HS 번호	2924 29 70

그림문자(GHS)

Fmoc-Lys(Ddiv)-OH 화학적 특성, 용도, 생산

개요
Fmoc-lys(IVDDE)-OH is a kind of FMOC (9H-fluoren-9-ylmethoxycarbon) and N-IVDDE (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl) double protected amino acid (lysine). It is important during peptide manufacturing. It is mainly used for the production of peptides which required to be modified on the Lysine side chain, including peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys side chain. It can also be used for the manufacturing of anionic cell penetrating peptide which is useful for intracellular delivery of therapeutic agents such as proteins and nucleic acids. The IVDDE group can be conveniently removed thorough hydrazine in the presence of acid labile groups.
화학적 성질
White to pale yellow powder
용도
Fmoc-Lys(ivDde)-OH is especially useful for preparing peptides selectively modified on the Lys sidechain, such as peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys sidechain. The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde. The ivDde group can be selectively removed with hydrazine in the presence of acid labile groups such as t-butyl and trityl based protecting groups.
Advantages
Fmoc-Lys(ivDde)-OH could be used to synthesize hetero-branched peptidesto avoid homodimer generation and construct heterodimers with a high ratio. This agent was used to generate Cellpenetrating peptides (CPP) and candidate peptides in one molecule[1].
참고 문헌
Wen-Qu, L. I., X. U. Hong-Yan, and L. I. Zhan-Xiong. "Synthesis of End N-Ivdde Protected Amino Acid."Chinese Journal of Synthetic Chemistry 17.2(2009):213-215.
http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid.php?id=101224
Chen, Hui Ting, et al. "Anionic cell penetrating peptide and its use for intracellular delivery." US, US8614194. 2013.
[1] Kozaki L, et al. Disulfide linked hetero dimeric peptide arrays for screening functional peptides inside cells. Journal of Bioscience and Bioengineering, 2019; 129: 613-618.

Fmoc-Lys(Ddiv)-OH 준비 용품 및 원자재

Fmoc-Lys(Ddiv)-OH 공급 업체

Send Inquriy