N,N-디메틸니트로사민

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H301：삼키면 유독함

  H330：흡입하면 치명적임

  H350：암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)

  H372：장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴

  H411：장기적 영향에 의해 수생생물에 유독함

• 예방조치문구

  P260：분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

  P271：옥외 또는 환기가 잘 되는 곳에서만 취급하시오.

  P284：호흡 보호구를 착용하시오.

  P301+P310：삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

  P304+P340：흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.

  P310：즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.

  P314：불편함을 느끼면 의학적인 조치·조언을 구하시오.

  P320：긴급히 (…) 처치를 하시오.

  P321：(…) 처치를 하시오.

  P330：입을 씻어내시오.

  P403+P233：용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.

  P405：밀봉하여 저장하시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

N,N-디메틸니트로사민 화학적 특성, 용도, 생산

• 화학적 성질

  N-Nitrosodimethylamine is a yellow oily liquid. Faint, characteristic odor.

• 물리적 성질

  Yellow, oily liquid with a faint, characteristic odor

• 용도

  N-Nitrosodimethylamine is a highly toxic semi-volatile organic compound and a suspected human carcinogen. It induces liver tumors in rats after chronic exposure to low doses (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.

• 생산 방법

  Dimethylnitrosamine (DMN) is prepared by the addition of acetic acid and sodium nitrite to dimethylamine. It came into industrial prominence in the manufacture of 1,1- dimethylhydrazine, a rocket fuel component, probably in the 1940s in Germany and in the mid-1950s in the United States. DMN is no longer used except for research. OSHA identified DMN as a carcinogen in 1974. In 1976, the last plant to make DMN was closed. DMN was first considered by IARC in 1971. The current IARC classification of DMN is 2A: “The agent is probably carcinogenic to humans, based upon positive cancer findings in animal studies.” For this reason, DMN is discussed here as an example of one of a large group of nitrosamines generally regarded as carcinogenic. IARC Monographs 1 and 17 and other publications discuss the toxicology, biochemistry, environmental impact, and carcinogenicity of many nitrosamines.

• 일반 설명

  Yellow oily liquid with a faint characteristic odor. Boiling point 151-153°C. Can reasonably be expected to be a carcinogen. Used as an antioxidant, as an additive for lubricants and as a softener of copolymers. An intermediate in 1,1-dimethylhydrazine production.

• 공기와 물의 반응

  Water soluble.

• 반응 프로필

  N-NITROSODIMETHYLAMINE is sensitive to exposure to light, especially ultraviolet light. Is stable at room temperature for more than 14 days in aqueous solution at neutral and alkaline pH in the absence of light. Slightly less stable at strongly acid pH at room temperature. Incompatible with strong oxidizing agents. Also incompatible with strong bases. Can be reduced by reducing agents. Incompatible with hydrogen bromide in acetic acid. Also photo chemically reactive.

• 건강위험

  N-nitrosodimethylamine (DMN) is a liver toxin and is carcinogenic in many species of test animals.

• 화재위험

  When heated to decomposition, N-NITROSODIMETHYLAMINE emits toxic fumes of nitrogen oxides. Avoid exposure to ultraviolet light.

• 잠재적 노출

  Nitrosodimethylamine was formerly used in the production of rocket fuels. Presently used as an antioxidant; as an additive for lubricants and as a softener of copolymers. It is used as an intermediate for 1,1-dimethylhydrazine.

• Carcinogenicity

  N-Nitrosodimethylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 운송 방법

  UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. PG I.

• Purification Methods

  Dry the nitrosamine over anhydrous K2CO3 or dissolve it in Et2O, dry it over solid KOH, filter, evaporate Et2O and distil the yellow oily residue through a 30cm fractionating column discarding the first fraction which may contain Me2N. Also dry over CaCl2 and distil it at atmospheric pressure. All operations should be done in an efficient fume cupboard as the vapors are TOXIC and CARCINOGENIC. [Fischer Chem Ber 8 1588 1875, Romberg Recl Trav Chim, Pays-Bas 5 248 1886, Hatt Org Synth Coll Vol II 211 1961, Krebs & Mandt Chem Ber 108 1130 1975.] 2,6-Dimethyl-2,4,6-octatriene see neo-alloocimene below.

• 비 호환성

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong acids, especially peracids strong bases. Sensitive to UV light. Should be stored in dark bottles.

• 폐기물 처리

  Pour over soda ash, neutralize with HCl, then flush to drain with large volumes of water. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

N,N-디메틸니트로사민 준비 용품 및 원자재

N,N-디메틸니트로사민 관련 검색