글리메피리드

한글명:글리메피리드

카스 번호93479-97-1

상품명:Glimepiride

CBNumberCB8318552

분자식C24H34N4O5S

포뮬러 무게490.62

MOL 파일93479-97-1.mol

동의어(한글)

글리메피리드

화학적 성질

녹는점	212.2-214.5 °C
밀도	1.29±0.1 g/cm3(Predicted)
저장 조건	room temp
용해도	DMSO: >10mg/mL
산도 계수 (pKa)	5.10±0.10(Predicted)
물리적 상태	고체
물리적 상태	단단한 모양
색상	하얀색
Merck	14,4440
BCS Class	2
CAS 데이터베이스	93479-97-1(CAS DataBase Reference)
EPA	1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans- 4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo- (93479-97-1)

위험 및 안전 성명

위험품 표기

Xn,Xi

위험 카페고리 넘버

21-36/38-46-62-63

안전지침서

25-26-36/37-53

WGK 독일

RTECS 번호

UX9363950

HS 번호

2935904000

NFPA 704:

	0
4		0

그림문자(GHS)

글리메피리드 MSDS

글리메피리드 화학적 특성, 용도, 생산

개요
Glimepiride, the first of a new generation of sulfonylurea drugs, was introduced in Sweden in 1995 as a first-line therapy to lower blood glucose in patients with type II diabetes. Sulfonylureas exert their hypoglycemic function primarily by direct stimulation of insulin secretion in glucose-insensitive pancreatic β-cells and GLUT translocation in insulin-resistant fat and muscle cells. Once-daily, orally administered glimepiride in diabetes patients showed a more rapid and longer lasting glucose-lowering effect than the commonly used agent glibenclamide. Glimepiride can be used either as a monotherapy or in combination with insulin.
화학적 성질
White Cyrstalline Solid
용도
Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.
일반 설명
Glimepiride is 3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]-carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide; thiscompound can also be named as the urea—see precedingdiscussion (Amaryl, generic). Combinations are availablewith rosiglitazone in the United States (Avandaryl tablets;mg glimepiride/mg rosiglitazone as maleate salt: 1/4,2/4, 4/4, 2/8, 4/8); and with pioglitazone (Duetact tablets;mg glimepiride/ mg pioglitazone as hydrochloride salt:2/30, 4/30).
생물학적 활성
Potent K ATP channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac K ATP channels with an IC 50 of 6.8 nM.

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