Bufalin

한글명:Bufalin

카스 번호465-21-4

상품명:Bufalin

CBNumberCB8219888

분자식C24H34O4

포뮬러 무게386.53

MOL 파일465-21-4.mol

화학적 성질

녹는점	242-243°
알파	D -20°
끓는 점	556.6±50.0 °C(Predicted)
밀도	1.226±0.06 g/cm3(Predicted)
저장 조건	2-8°C
용해도	DMSO:36.0(Max Conc. mg/mL);93.14(Max Conc. mM) DMF:25.0(Max Conc. mg/mL);64.68(Max Conc. mM) Ethanol:27.5(Max Conc. mg/mL);71.15(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.78(Max Conc. mM)
산도 계수 (pKa)	15.01±0.70(Predicted)
물리적 상태	흰색에서 회백색 고체
색상	White to off-white
InChIKey	QEEBRPGZBVVINN-ONGIWDLKSA-N

위험 및 안전 성명

위험품 표기	T+
위험 카페고리 넘버	28
안전지침서	28-36/37-45
유엔번호(UN No.)	UN 3462 6.1/PG 2
WGK 독일	3
RTECS 번호	EI2962500
위험 등급	6.1(a)
포장분류	II
HS 번호	29322090

그림문자(GHS)

Bufalin MSDS

Bufalin 화학적 특성, 용도, 생산

용도
Bufalin has been used:
- to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs)
- as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes
- to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib
정의
ChEBI: A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.
일반 설명
Bufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis. Bufalin is a cardiotonic steroid and is digoxin-like component of Chan Su.
위험도
Toxic.
효소 저해제
This cardioactive C-24 steroid (FW = 386.52 g/mol; CAS 465-21-4; Solubility: 5 mg/mL chloroform, 25 mg/mL DMSO), also named 3,14- dihydroxybufa-20,22-dienolide;5β,20(22)-bufadienolide-3β,14-diol and 3β,14-dihydroxy-5β,20(22)-bufadienolide, is the major digoxin-like immunoreactive component of Chansu, a traditional Chinese medicine prepared from the skin and venom-containing parotid gland of a poisonous toad. Bufalin increases the doubling time of three prostate cancer cell lines, inducing apoptosis and the caspase-3 activity. Expression of other proapoptoptic factors, such as mitochondrial Bax and cytosolic cytochrome c, were also increased. Bufalin also reduces serum-induced invasiveness of human hepatocellular cancer SK-Hep1 cells, markedly inhibiting MMP-2 and MMP-9 activities. It also attenuates phosphoinisitide-3-kinase (PI3K) and AKT phosphorylation was associated with reduced levels of NF- κB. Bufalin also suppresses protein levels of FAK, Rho A, VEGF, MEKK3, MKK7, and uPA. Such observations indicate that bufalin is as an antiinvasive agent that inhibits MMP-2 and -9 and alters PI3K/AKT and NF- κB signaling pathways.

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