숙시닐콜린

숙시닐콜린 화학적 특성, 용도, 생산

• 개요

  Succinylcholine is the only therapeutically used depolarizing neuromuscular blocker. Unlike nondepolarizing substances, succinylchloride is not a competitive antagonist; conversely, it is a more stable agonist than acetylcholine. In this manner, succinylcholine differs from acetylcholine only in duration—it lasts longer, causing a more stable depolarization. Thus the process of repolarization is blocked and the muscles relax. During this period, muscles that cause fine movement (ocular, facial, neck) are the most sensitive and are blocked first, after which muscles of the extremities are blocked, and finally the most stable respiratory muscles. Restoration occurs upon completion of drug action.

• 용도

  Therapeutic use of succinylcholine consists of preventing involuntary patient movement. It is used for brief operations, intubation of the trachea, and other endoscopic procedures. Synonyms of this drug are listenon, midarine, sucostrin, ditilin, and others.

• 정의

  ChEBI: A quaternary ammonium ion that is the bis-choline ester of succinic acid.

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