글라브리딘

한글명:글라브리딘

카스 번호59870-68-7

상품명:Glabridin

CBNumberCB7670448

분자식C20H20O4

포뮬러 무게324.37

MOL 파일59870-68-7.mol

동의어(한글)

글라브리딘

화학적 성질

녹는점	154～155℃
끓는 점	518.6±50.0 °C(Predicted)
밀도	1.257±0.06 g/cm3(Predicted)
인화점	267℃
저장 조건	room temp
용해도	DMSO: 용해성5mg/mL, 투명(가온)
물리적 상태	가루
산도 계수 (pKa)	9.66±0.40(Predicted)
색상	흰색에서 밝은 갈색까지
BRN	7141956
안정성	흡습성
InChI	InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChIKey	PMPYOYXFIHXBJI-ZDUSSCGKSA-N
SMILES	C1(O)=CC=C([C@@H]2COC3=C4C=CC(C)(C)OC4=CC=C3C2)C(O)=C1
LogP	4.260 (est)
CAS 데이터베이스	59870-68-7(CAS DataBase Reference)

위험 및 안전 성명

안전지침서

24/25

WGK 독일

HS 번호

29329990

NFPA 704:

	0
3		0

그림문자(GHS)

글라브리딘 화학적 특성, 용도, 생산

화학적 성질
White to tan powder, insoluble in water, easily soluble in organic solvents such as ethanol, propylene glycol, 1,3-butanediol, etc.
용도
Glabridin is a compound extracted from Licorice (root) shows properties that are cytotoxic, antimicrobial, estrogenic and anti-proliferative.
정의
ChEBI: Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.
benefits
Glabridin has strong antibacterial effects and can prevent inflammation, pigmentation, and rough skin caused by ultraviolet rays. It can also remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. Moreover, it can inhibit the activity of tyrosinase and the conversion of dopachrome, making it an effective and environmentally-friendly additive for whitening and freckle removal in cosmetics. Additionally, Glabridin possesses similar abilities to scavenge oxygen free radicals as SOD (superoxide dismutase) and vitamin E, making it a powerful antioxidant.
Mode of action
Glabridin[59870-68-7] is one of the main flavonoid components in Glycyrrhiza glabra. It shows a strong anti-free radical oxidation effect in the cytochrome P450/NADPH oxidation system, which can significantly inhibit the free radicals produced in the metabolic process of the body, to avoid oxidative damage to oxidation-sensitive biological macromolecules (low-density lipoprotein LDL, DNA) and the cell wall, etc. by free radical oxidation. Thus, it can prevent certain pathological changes related to free radical oxidation, such as atherosclerosis, and cellular aging. In addition, Glabridin has some hypolipidemic and hypotensive effects.
참고 문헌
Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium‐induced colitis DOI:10.1111/j.1365-2249.2007.03539.x
Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin DOI:10.1016/J.FOODHYD.2019.01.031
A novel ?uorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors DOI:10.1016/j.snb.2019.126864
Glavonoid, a possible supplement for prevention of ATTR amyloidosis DOI:10.1016/j.heliyon.2021.e08101
Tian, M. et al.: Int. J. Mol. Sci., 9, 571 (2008); Simmler, C. et al.: Fitoterapia, 90, 160 (2013);

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