모노메틸푸마르산염

한글명:모노메틸푸마르산염

카스 번호2756-87-8

상품명:Monomethyl fumarate

CBNumberCB7505423

분자식C5H6O4

포뮬러 무게130.1

MOL 파일2756-87-8.mol

동의어(한글)

모노메틸푸마르산염

화학적 성질

녹는점	144-145 °C (lit.)
끓는 점	250.0±23.0 °C(Predicted)
밀도	1.37 g/cm3
저장 조건	2-8°C
용해도	클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)	3.40±0.10(Predicted)
물리적 상태	고체
물리적 상태	단단한 모양
색상	회백색
최대 파장(λmax)	209nm(MeOH)(lit.)
CAS 데이터베이스	2756-87-8(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

안전지침서

26-39

WGK 독일

HS 번호

29171900

NFPA 704:

	0
3		0

그림문자(GHS)

모노메틸푸마르산염 화학적 특성, 용도, 생산

개요
Monomethyl fumarate (MMF), a bioactive metabolite of fumaric acid ester, is an immunotherapy for psoriasis that causes decreased production of Th1 cytokines and lymphocytopenia. Monomethyl fumarate was shown to decrease DC response to LPS and decreased IL-12p70 and IL-10 production.
화학적 성질
Off-White Solid
용도
Monomethyl fumarate is used to treat the relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. This medicine will not cure MS, but it may slow some of the disabling effects and decrease the number of relapses of the disease.
Fumaric Acid Monomethyl Ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Fumaric Acid Monomethyl Ester is potent nicotinic acid receptor agonist. Fumaric Acid Monomethy l Ester has also been shown to selectively stimulate of T helper 2 cytokine response.
정의
ChEBI: Monomethyl fumarate is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1. It has a role as an immunomodulator, an antioxidant and a drug metabolite. It is an enoate ester, a methyl ester and a dicarboxylic acid monoester. It derives from a fumaric acid.
제조 방법
Monomethyl fumarate was synthesized by maleic anhydride and methanol. monomethyl fumarate could inhibit the growth of mold, and the storage time of feed could be prolonged.
Synthesis Reference(s)
The Journal of Organic Chemistry, 23, p. 1559, 1958 DOI: 10.1021/jo01104a608

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