Cefdinir

한글명:Cefdinir

카스 번호91832-40-5

상품명:Cefdinir

CBNumberCB7483101

분자식C14H13N5O5S2

포뮬러 무게395.41

MOL 파일91832-40-5.mol

화학적 성질

녹는점	>180°C dec.
밀도	1.89±0.1 g/cm3(Predicted)
저장 조건	Keep in dark place,Sealed in dry,2-8°C
용해도	묽은 HCl: 약간 용해됨
산도 계수 (pKa)	9.70(at 25℃)
물리적 상태	고체
물리적 상태	단단한 모양
색상	연한 노란색에서 밝은 노란색까지
수용성	물에 용해됨
최대 파장(λmax)	295nm(DMSO)(lit.)
Merck	14,1920
BCS Class	4
InChIKey	RTXOFQZKPXMALH-GHXIOONMSA-N
SMILES	N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\O)=O)C1=O)SCC(C=C)=C2C(O)=O
CAS 데이터베이스	91832-40-5(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

RTECS 번호

XI0367250

HS 번호

2941906000

독성

LD50 orl-rat: >5600 mg/kg IYKEDH 23,93,1992

NFPA 704:

	0
2		0

그림문자(GHS)

Cefdinir MSDS

Cefdinir 화학적 특성, 용도, 생산

개요
Cefdinir is an orally active, beta-lactamase stable cephalosporin with a broad spectrum of activity. Compared to other oral cephalosporins, cefdinir is more potent against Gram-positive bacteria, especially Staphylococci. Its activity against Gram-negative bacteria such as E.coli,K. pneumoniae and P.mirabilis is similar to cefixime, but superior to cefaclor and cephalexin.
화학적 성질
Pale Yellow Solid
용도
A Cephalosporin antibiotic structurally similar to Cefixime
정의
ChEBI: A cephalosporin compound having 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups.
Antimicrobial activity
An oral cephalosporin similar in structure to cefixime, but with a slightly modified side chain at the 7-amino position. Activity is similar to that of cefixime, but it is more active, especially against staphylococci. It is not hydrolyzed by staphylococcal or the common plasmid-mediated enterobacterial β-lactamases. An enhancing effect on phagocytosis has been demonstrated in vitro.
Oral absorption is about 35%. A 200 mg oral dose achieves a plasma concentration of 1 mg/L after c. 3 h. Absorption is reduced after a fatty meal. Concentrations equal to or higher than corresponding plasma levels were present in blister fluid 6–12 h after administration of an oral dose. The plasma halflife is 1.5 h. Protein binding is 60–70%. A total of 12–20% of the dose was excreted in the urine within 12 h, the renal elimination declining with increasing dose. The elimination half-life and peak plasma concentration are increased in renal failure. About 60% of the drug is removed by hemodialysis.
Side effects and uses are those common to oral cephalosporins.
Safety Profile
Moderately toxic by ingestion andintravenous routes. Low toxicity by intraperitoneal andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic vapors ofNOx and SOx.

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