Carbidopa Monohydrate

한글명:Carbidopa Monohydrate

카스 번호38821-49-7

상품명:Carbidopa Monohydrate

CBNumberCB7445183

분자식C10H16N2O5

포뮬러 무게244.25

MOL 파일38821-49-7.mol

화학적 성질

저장 조건	Keep in dark place,Inert atmosphere,Room temperature
용해도	물에 약간 용해되고, 에탄올(96%)에 매우 약간 용해되며, 염화메틸렌에는 거의 용해되지 않습니다. 묽은 무기산 용액에 용해됩니다.
물리적 상태	Solid
색상	흰색에서 황백색까지
CAS 데이터베이스	38821-49-7(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

RTECS 번호

MW5300000

위험 등급

IRRITANT

HS 번호

2928002500

독성

mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.

NFPA 704:

	0
2		0

그림문자(GHS)

Carbidopa Monohydrate 화학적 특성, 용도, 생산

화학적 성질
white or yellowish-white powder. almost odorless. combined with levodopa for Parkinson's disease and Parkinson's syndrome.
용도
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.
정의
ChEBI: Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug, a dopaminergic agent and an antidyskinesia agent. It is a member of hydrazines, a hydrate, a monocarboxylic acid and a member of catechols. It contains a carbidopa (anhydrous).
일반 설명
Carbidopa, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, is a whitecrystalline powder, slightly soluble in water (pK_a＝7.8).Carbidopa is absorbed slower than levodopa and is 36%plasma protein bound.Carbidopa is metabolized to twomain metabolites (α-methyl-3-methoxy-4-hydroxyphenylpropionicacid and α-methyl-3,4-dihydroxyphenylpropionicacid). These two metabolites are primarily eliminated in theurine unchanged or as glucuronide conjugates. Unchangedcarbidopa accounts for 30% of the total urinary excretion.No drug interactions have been described.

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