비알라포스

한글명:비알라포스

카스 번호35597-43-4

상품명:BIALAPHOS

CBNumberCB7329454

분자식C11H22N3O6P

포뮬러 무게323.28

MOL 파일35597-43-4.mol

동의어(한글)

L-2-아미노-4-[(히드록시)(메틸)-호스피노일]브치릴-L-아라닐-L-알라닌

비알라포스

빌라나포스

화학적 성질

녹는점	159-161 C
끓는 점	793.2±60.0 °C(Predicted)
밀도	1.330±0.06 g/cm3(Predicted)
저장 조건	Store dry at -4
산도 계수 (pKa)	2.86±0.50(Predicted)

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	20/21/22-36/37/38
안전지침서	26-36

그림문자(GHS)

비알라포스 화학적 특성, 용도, 생산

개요
Bilanofos is a natural product formed during the fermentation of Streptomyces hygroscopicus. It is readily soluble in water and insoluble in organic solvents such as acetone, ethanol, benzene, and hexane (9).
Bilanophos is a GS inhibitor. In the plant, bilanofos is metabolized to L-glufosinate, which inhibits the enzyme GS. Ammonium ions rapidly accumulate in the plant, and photosynthesis is inhibited, leading to rapid death of the plant. It is inactivated in soil.
역사
Bialaphos[peptide derivative of PPT (PPT linked to two L-alanine moieties)] was originally isolated from cultures of Streptomyces viridochromogenes (87) and Streptomyces hygroscopicus (88). L-PPT is the natural isomer, and it was the first natural amino acid found to contain a phosphinic group. PPT strongly inhibited glutamine synthetase activity in E. coli (87), and Hoechst Ag patented it as a herbicide after its phytotoxicity was discovered (89). Bialaphos was patented as a herbicide (90) and is marketed in Japan (91). Glufosinate (ammonium salt of PPT) is the synthesized commercial product. Bialaphos is hydrolyzed by plant and soil microbial peptidases to yield the active herbicide (PPT) (92–94). PPT is also rapidly degraded, with half-life of 4 to 7 days in soils (95). In a test of 300 bacterial isolates from soil, all strains degraded L-PPT to the 2-oxo analog of PPT via transamination (96).
정의
ChEBI: A tripeptide comprising one L-phosphinothricyl and two L-alanyl units joined in sequence.
Origin
The compound was launched as a nonselective contact herbicide in 1984.
신진 대사 경로
When 14C-bialaphos [L-2-amino-4- [(hydroxy)(methyl)phosphinoyl]butyryl-L-alanyl-L- alanine] is administered in an aqueous solution to mice, the metabolite of bialaphos which is identified as 2-amino-4-[(hydroxy)(methyl)phosphinoyl]butyric acid is excreted in the feces and urine.
신진 대사
The major metabolite following oral administration in the mouse was 2-amino-4- (hydroxy)(methyl)phosphinyl)butyric acid, which was eliminated in feces.

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