ChemicalBook 제품 카탈로그 API 항생제 아미노 글리코 시드 약물 O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D-

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 구조식 이미지

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D-

한글명:O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D-

카스 번호32986-56-4

상품명:Tobramycin

CBNumberCB7154445

분자식C18H37N5O9

포뮬러 무게467.52

MOL 파일32986-56-4.mol

동의어(한글)

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D-

화학적 성질

녹는점	178 °C
알파	D20 +129° (c = 1 in water)
끓는 점	570.01°C (rough estimate)
밀도	1.3458 (rough estimate)
굴절률	143 ° (C=4, H2O)
저장 조건	Keep in dark place,Inert atmosphere,2-8°C
용해도	H₂O: 50 mg/mL, 투명, 희미한 노란색
산도 계수 (pKa)	pKa 6.7 (Uncertain);8.3 (Uncertain);9.9 (Uncertain)
물리적 상태	흰색에서 회백색 고체
색상	흰색에서 황백색까지
수용성	물에 용해됨
Merck	14,9490
BRN	1357507
안정성	흡습성

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-37/39

WGK 독일

RTECS 번호

WK2100000

F 고인화성물질

3-10

HS 번호

29419090

유해 물질 데이터

32986-56-4(Hazardous Substances Data)

독성

LD50 in mice, rats (mg/kg): 441, 969 s.c. (Welles)

NFPA 704:

	0
2		0

그림문자(GHS)

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- MSDS

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 화학적 특성, 용도, 생산

개요
Tobramycin is one component (factor 6) of a mixture produced by fermentation of Streptomyces tenebrari us. Lacking the C-3′ hydroxyl group, it is not a substrate for APH(3′)-1 and APH(3′)-II and so has an intrinsically broader spectrum than kanamycin. It is a substrate, however, for adenylation at C-2′ by ANT (2′) and acetylation at C-3 by AAC(3)-I and AAC(3)-II and at C-2′ by AAC(2′).
화학적 성질
White or almost white powder.
용도
Tobramycin is an aminoglycoside antibiotic.
정의
ChEBI: A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.
Indications
Tobramycin is highly active with respect to Gram-negative microorganisms (blue-pus bacillus and gastric bacilli, rabbit fever, serratia, providencia, enterobacteria, proteus, salmonella, shigella), as well as Gram-positive microorganisms (staphylococci, including those resistant to penicillin and some cephalosporins), and a few strains of streptococci.
It is used for severe bacterial infections: peritonitis, sepsis, meningitis, osteomyelitis, endocarditis, pneumonia, pleural empyema, pulmonary abscess, purulent skin infections and soft tissue infections, and infections of the urinary tract caused by microorganisms that are sensitive to the drug. Synonyms of this drug are nebicine, obracine, and others.
Antimicrobial activity
In-vitro activity against Ps. aeruginosa is usually somewhat greater than that of gentamicin; against other organisms activity is similar or a little lower. Other Pseudomonas species are generally resistant, as are streptococci and most anaerobic bacteria. Other organisms usually susceptible in vitro include Acinetobacter, Legionella and Yersinia spp. Alkaligenes, Flavobacterium spp. and Mycobacterium spp. are resistant. It exhibits bactericidal activity at concentrations close to the MIC and bactericidal synergy typical of aminoglycosides in combination with penicillins or cephalosporins.
원료
It is inactivated by many aminoglycoside-modifying enzymes that inactivate gentamicin. However, AAC(3′)-I does not confer tobramycin resistance and AAC(3′)-II confers a lower degree of tobramycin resistance than of gentamicin resistance. Conversely, ANT(4′) confers tobramycin but not gentamicin resistance, as do some types of AAC(6′). Overproduction of APH(3′), conferring a low degree of resistance to tobramycin (MIC 8 mg/L), but not gentamicin (MIC 2 mg/L), was ascribed to ‘trapping’ rather than phosphorylation.
Resistance rates are generally similar to those of gentamicin, although they may vary locally because of the prevalence of particular enzyme types.
생물학적 활성
Pharmacologically, tobramycin is quite similar to gentamicin. The drug is somewhat more active against Ps. aeruginosa than gentamicin. Tobramycin also acts synergistically with penicillin, but to a lesser degree than gentamicin.
Clinical Use
Severe infections caused by susceptible micro-organisms Ps. aeruginosa infections, including chronic pulmonary infections in cystic fibrosis (administration by injection or nebulizer)
For practical purposes use is identical to that of gentamicin, except possibly for Pseudomonas infection, where it has somewhat greater activity against gentamicin-susceptible and some gentamicin-resistant strains. Its value as a substitute for gentamicin in the speculative treatment of severe undiagnosed infection is offset by its lower activity against other organisms that may be implicated.
It has been used extensively to treat Ps. aeruginosa infections in patients with cystic fibrosis.

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 준비 용품 및 원자재

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 공급 업체

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 관련 검색

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