7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

그림문자(GHS)

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 화학적 특성, 용도, 생산

• 용도

  7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.

• 주요 응용

  7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.

• Synthesis

  1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
  2.Stir the mixture for 17 hours at 25°C.
  3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
  4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
  5.Stir the mixture for 30 minutes and filter the solid material.
  6.Wash the mixture with 1 L of water, suck dry and unload the material.
  7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
  

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