콜레스틸란

콜레스틸란 화학적 특성, 용도, 생산

• 개요

  Colestimide was launched in Japan for the treatment of hyperlipidemia and hypercholesterolemia. It is a newly developed methyl imidazoleepichlorhydrin copolymer; this anion exchange resin works as a powerful bile acid sequestrant, thus increasing the rate of conversion of cholesterol to bile acids in the liver which may lead to enhancement of the rate of LDL removal. In animal models and humans, Colestimide proved to be more potent than cholestyramine and seems to be better tolerated. It reduced plasma levels of total and LDL cholesterol and did not alter HDL and triglyceride levels. Colestimide can be used in monotherapy or co-administered with HMG-CoA reductase inhibitors.

• 용도

  Colestilan, is a copolymer of 2-methyl-1H-imidazole and epichlorohydrin, and a bile acid sequestrans, that can be used for the treatment of hypercholesterolemia and dyslipidemia.

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