FORTIMICIN

FORTIMICIN 화학적 특성, 용도, 생산

• 정의

  ChEBI: An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at posi ion 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is adm nistered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms.

• Antimicrobial activity

  A pseudodisaccharide aminoglycoside produced by Micromonospora olivoasterospora. Formulated as the sulfate. Intrinsic activity is similar to that of amikacin for most groups of organisms, but activity against Ps. aeruginosa is relatively poor. It is resistant to many aminoglycoside-modifying enzymes, but is sensitive to AAC(3) and the APH(2″)/AAC(6′) bifunctional enzyme.
  Peak concentrations of 10–12 mg/L were found in the blood following 200 mg intravenous or intramuscular administration to volunteers. The plasma half-life was 1.5–2 h. Over 85% of the drug was recovered in urine during the 8 h following administration.
  Toxicity and side effects are similar to those observed with other aminoglycosides. Where the drug is available it is used instead of amikacin in the treatment of infections caused by susceptible organisms.

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