Firocoxib

한글명:Firocoxib

카스 번호189954-96-9

상품명:Firocoxib

CBNumberCB71011736

분자식C17H20O5S

포뮬러 무게336.4

MOL 파일189954-96-9.mol

화학적 성질

녹는점	78-80°C
끓는 점	563.9±50.0 °C(Predicted)
밀도	1.31
저장 조건	Sealed in dry,Store in freezer, under -20°C
용해도	클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
용해도	클로로포름(약간), 에틸아세테이트(약간), 메탄올(약간)에 용해됨
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 황백색까지
InChI	InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
InChIKey	FULAPETWGIGNMT-UHFFFAOYSA-N
SMILES	O1C(C)(C)C(C2=CC=C(S(C)(=O)=O)C=C2)=C(OCC2CC2)C1=O

그림문자(GHS)

Firocoxib 화학적 특성, 용도, 생산

개요
Firocoxib is a selective inhibitor of COX-2 (IC₅₀s = 0.13 and 7.5 μM for COX-2 and COX-1, respectively, in isolated cat blood). It inhibits LPS-induced production of prostaglandin E₂ (PGE₂; ) in isolated dog, horse, and cat whole blood ex vivo. Firocoxib decreases lameness, induces analgesia, and improves range of motion in dogs and horses with osteoarthritis when administered at doses of 5 and 0.1 mg/kg per day, respectively. Formulations containing firocoxib have been used in dogs and horses with osteoarthritis.
화학적 성질
White Solid
용도
A selective cyclooxygenase-2-(COX-2) inhibitor. Anti-inflammatory; analgesic.
정의
ChEBI: An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoart ritis in horses and dogs.
Mechanism of action
Firocoxib is a non-steroidal anti-inflammatory drug (NSAID) belonging to the Coxib group, which acts by selective inhibition of cyclooxygenase-2 (COX-2)-mediated prostaglandin synthesis. Cyclooxygenase is responsible for the generation of prostaglandins. COX-2 is the isoform of the enzyme induced by pro-inflammatory stimuli and has been postulated to be primarily responsible for synthesizing prostanoid mediators of pain, inflammation, and fever. Coxibs, therefore, display analgesic, anti-inflammatory, and antipyretic properties. COX-2 is also thought to be involved in ovulation, implantation, and closure of the ductus arteriosus and central nervous system functions (fever induction, pain perception, and cognitive function).

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