N-숙신이미딜4-(N-말레이미도메틸)시클로헥산-1-카르복실레이트

한글명:N-숙신이미딜4-(N-말레이미도메틸)시클로헥산-1-카르복실레이트

카스 번호64987-85-5

상품명:SMCC crosslinker

CBNumberCB6748487

분자식C16H18N2O6

포뮬러 무게334.32

MOL 파일64987-85-5.mol

동의어(한글)

N-숙신이미딜4-(N-말레이미도메틸)시클로헥산-1-카르복실레이트

화학적 성질

녹는점	180-182 °C (lit.)
끓는 점	501.7±42.0 °C(Predicted)
밀도	1.42±0.1 g/cm3(Predicted)
저장 조건	-20°C
용해도	클로로포름: 50mg/mL
물리적 상태	가루
산도 계수 (pKa)	-2.24±0.20(Predicted)
색상	흰색에서 황백색까지
감도	Moisture & Light Sensitive
BRN	1555271
InChI	InChI=1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2
InChIKey	JJAHTWIKCUJRDK-UHFFFAOYSA-N
SMILES	C1(C(ON2C(=O)CCC2=O)=O)CCC(CN2C(=O)C=CC2=O)CC1
CAS 데이터베이스	64987-85-5(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-36-60-37

WGK 독일

F 고인화성물질

10-21

HS 번호

29280000

NFPA 704:

	1
2		0

그림문자(GHS)

N-숙신이미딜4-(N-말레이미도메틸)시클로헥산-1-카르복실레이트 화학적 특성, 용도, 생산

개요
SMCC crosslinker is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then can be added to an aqueous crosslinking reaction. SMCC crosslinking reagent is permeable across the lipid bilayer of the cell membrane and can be used to crosslink intracellular proteins and peptides.
화학적 성질
White Crystalline Solid
용도
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(abTaIII)2 fragments to l-B-galactosidase. Conjugates hIgG to alkaline phosphatase.Spacer Arm: 11.6 Angstroms.
정의
ChEBI: Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate is an N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid. It is a member of maleimides and a N-hydroxysuccinimide ester.
일반 설명
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
화학 반응
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a non-cleavable and membrane permeable crosslinker. It contains an amine-reactive N -hydroxysuccinimide (NHS ester) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7-9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. The maleimide groups of SMCC and Sulfo-SMCC and are unusually stable up to pH 7.5 because of the cyclohexane bridge in the spacer arm.

N-숙신이미딜4-(N-말레이미도메틸)시클로헥산-1-카르복실레이트 준비 용품 및 원자재

N-숙신이미딜4-(N-말레이미도메틸)시클로헥산-1-카르복실레이트 공급 업체

N-숙신이미딜4-(N-말레이미도메틸)시클로헥산-1-카르복실레이트 관련 검색

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