크로타미톤

한글명:크로타미톤

카스 번호483-63-6

상품명:Crotamiton

CBNumberCB6451611

분자식C13H17NO

포뮬러 무게203.28

MOL 파일483-63-6.mol

동의어(한글)

크로타미톤

화학적 성질

녹는점	25°C
끓는 점	153-155 °C/13 mmHg (lit.)
밀도	0.987 g/mL at 25 °C (lit.)
굴절률	n20/D 1.54(lit.)
인화점	>230 °F
저장 조건	2-8°C
용해도	에탄올: 가용성
산도 계수 (pKa)	1.14±0.50(Predicted)
물리적 상태	<25°C Solid,>25°C Liquid
색상	무색~밝은 갈색
수용성	물(1:500), 알코올, 메탄올, 에테르 및 에탄올에 용해됩니다.
Merck	13,2622
안정성	감광성
InChIKey	DNTGGZPQPQTDQF-XBXARRHUSA-N
LogP	3.099 (est)
CAS 데이터베이스	483-63-6(CAS DataBase Reference)
NIST	Crotamiton(483-63-6)
EPA	Crotamiton (483-63-6)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

22-36/38-43

안전지침서

26-36

WGK 독일

RTECS 번호

GQ7000000

HS 번호

2924296000

NFPA 704:

	1
2		0

그림문자(GHS)

크로타미톤 MSDS

크로타미톤 화학적 특성, 용도, 생산

개요
Crotamiton is available as a 10% cream for the treatment of scabies, although it is less effective than pyrethrins or permethrin. Because crotamiton may need to be applied a second time for successful treatment of scabies but the pyrethrins or permethrin require a single application, poor patient compliance with crotamiton may reduce its effectiveness. The advantage of crotamiton over lindane comes from the fact that lindane has potential neurotoxicity if absorbed especially in infants and children, whereas crotamiton has less systemic neurotoxicity.
화학적 성질
N-Ethyl-o-crotonotoluidide is colourless or pale yellow, oily liquid
용도
N-Ethyl-o-crotonotoluidide (Crotamiton) was used to treat scabies and various pruritic dermatoses.
Indications
Crotamiton (N-ethyl-o-crotonotoluide, Eurax) is a synthetic chloroformate salt used for the prevention and treatment of scabies, although cure rates tend to be lower for the same number of applications compared with lindane and permethrin. It may have an antipruritic effect independent of its scabetic effect. Its mechanism of action is unknown. It is not effective as a pediculicide.
Crotamiton (10% N-ethyl-o-crotonotoluide, Eurax) cream applied twice and left on during a 48-hour period is usually effective against scabies and has been reported to act as an antipruritic agent.
정의
ChEBI: The amide resulting from the formal condensation of crotonic acid with N-ethyl-2-methylaniline. A colourless or pale yellow oily liquid, it is used in the treatment of pruritus (itching) by producing a counter-irritation: as it evaporate from the skin, it produces a cooling effect that diverts attention away from the itching. It has also been used as an acaricide in the treatment of scabies, though more effective drugs are usually preferred.
Clinical Use
N-Ethyl-N-(2-methylphenyl)-2-butenamide, or N-ethyl-ocrotonotoluidide(Eurax), is a colorless, odorless oily liquid.It is virtually insoluble in water but soluble in most organicsolvents.
Crotamiton is available in 10% concentration in a lotionand a cream intended for the topical treatment of scabies. Its antipruritic effect is probably because of a local anestheticaction.
부작용
The most common side effect reported for crotamiton is skin irritation.

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