옥시테트라시클린

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H411：장기적 영향에 의해 수생생물에 유독함

• 예방조치문구

  P201：사용 전 취급 설명서를 확보하시오.

  P202：모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.

  P273：환경으로 배출하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P308+P313：노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.

  P391：누출물을 모으시오.

옥시테트라시클린 MSDS

• 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

옥시테트라시클린 화학적 특성, 용도, 생산

• 물성

  옥시테트라사이클린(C22H24N2O9)은 분자량이 496.44 이며 노란색부터 갈색까지 있다. 물에 용해성이 있으며 에탄올, 메탄올에 용해되고 에테르, 클로로포름에 용해되지 않는다.

• 개요

  옥시테트라사이클린은 Streptomyces rimosus가 생산하는 테트라사이클린 항생제의 일종이다. 다른 테트라사이클린처럼 옥시테트라사이클린도 다양한 일반적인 감염성 질병을 치료하기 위해 사용된다. 흡수가 좋아서 테트라사이클린보다 더 선호된다.

• 용도

  옥시테트라사이클린은 여러 박테리아성 감염의 치료 및 예방에 광범위하게 사용되는 항생제이다. 코코야자 나무의 치명적인 황변을 억제하는 데에도 사용된다.

• 개요

  Oxytetracycline also is one of the classic tetracyclines. It is produced by fermentation of Streptomyces rimosis and other soil microorganisms. The most hydrophilic tetracycline on the market, it has largely now been replaced by its semisynthetic descendants. It is primarily used today for IM injections.

• 화학적 성질

  beige to light yellow crystalline powder

• 용도

  Oxytetracycline(Terramycin) was the second of the broad-spectrum tetracycline group of antibiotics to be discovered. Oxytetracycline works by interfering with the ability of bacteria to produce proteins that are essential to them. Without these proteins t

• 정의

  ChEBI: A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae /ital> (respiratory infections), and Diplococcus pneumoniae.

• Antimicrobial activity

  It is slightly less active than other tetracyclines against most common pathogenic bacteria.

• Pharmaceutical Applications

  A fermentation product of certain strains of Streptomyces rimosus, supplied as the dihydrate or hydrochloride for oral or parenteral administration.

• Pharmacokinetics

  Oral absorption： c.60%
  C_max 500 mg oral： 3–4 mg/L after 2–4 h
  Plasma half-life： c.9 h
  Volume of distribution： c.1.8 L/kg
  Plasma protein binding： 20–35%
  Oxytetracycline is moderately well absorbed from the upper gastrointestinal tract. Food decreases plasma levels by approximately 50%. Although widely distributed in the tissues, it achieves lower concentrations than related agents such as minocycline. Sputum concentrations of 1 mg/L have been recorded on a daily dosage of 2 g. Approximately 60% is excreted in the urine and the half-life is prolonged in renal insufficiency.

• Clinical Use

  It offers no unique therapeutic advantages, although it is one of the cheaper preparations.

• 부작용

  Gastrointestinal intolerance is responsible for most side effects, and tends to be more severe than with other tetracyclines. Esophageal irritation may result from the local effects of the swallowed drug. Potentially serious adverse reactions have included neuromuscular paralysis following intravenous administration to patients with myasthenia gravis. Thrombocytopenic purpura and lupus erythematosus syndrome have been reported, although a direct role for the drug in the latter remains uncertain. Apart from the effect on nitrogen balance common to many tetracyclines, a metabolic effect on glucose homeostasis has been noted in type 1 diabetes mellitus. Allergic contact sensitivity reactions have also been reported.

• Purification Methods

  Terramycin crystallises (as dihydrate) from water or aqueous EtOH and is soluble in MeOH, EtOH, Me2CO and H2O (0.25mg/mL at 25o ) but insoluble in Et2O and pet ether. It is amphoteric, and an aqueous solution has pH 2.0-5.0. It has max at 247, 275 and 353nm in 0.1 M phosphate (pH 4.5). [Finlay et al. Science 111 85 1951.] The hydrochloride, [2058-46-0] M 496.9 [Beilstein 14 IV 2630], crystallises from MeOH in needles and from H2O at 50o it forms plates. Terramycin has also been purified via the hydrochloride by dissolving it in H2O, adjusting to pH 6, and the solid is filtered off after 1hour. The crystals of the dihydrate are dried to constant weight in vacuum/CaCl2/25o. Drying at 60o in vacuo gives the anhydrous base m 184.5-185.5o (sintering at 180o). The dihydrate has m 181-182o. Its optical rotation in MeOH decreases from [] D 25 +26o (c 0.5%) to [] D 25 +11.3o after standing for 16hours. It forms a sodium salt and a CaCl2 complex. [Regna et al. J Am Chem Soc 73 4211 1951, Beilstein 14 IV 2633.]

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