OXACILLIN SODIUM

한글명:OXACILLIN SODIUM

카스 번호1173-88-2

상품명:OXACILLIN SODIUM

CBNumberCB6278850

분자식C19H18N3NaO5S

포뮬러 무게423.42

MOL 파일1173-88-2.mol

화학적 성질

녹는점	188°C
저장 조건	Inert atmosphere,2-8°C
용해도	H2O: 용해성50mg/mL
물리적 상태	수정 같은
색상	무색 또는 흰색
BRN	4098179

위험 및 안전 성명

위험품 표기

안전지침서

22-24/25

WGK 독일

RTECS 번호

XH9100000

독성

cat,LDLo,oral,> 750mg/kg (750mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 322, 1965.

NFPA 704:

	0
2		0

그림문자(GHS)

OXACILLIN SODIUM 화학적 특성, 용도, 생산

화학적 성질
Crystalline
용도
Oxacillin sodium salt is a narrow spectrum beta-lactam antibiotic. It can be used in analytical study of combination of reversed phase liquid chromatography and zwitterion exchange-reversed phase-hydrophilic interaction mixed-mode liquid chromatography coupled with mass spectrometry for anal. of antibiotics and their impurities.
Clinical Use
Oxacillin sodium, (5-methyl3-phenyl-4-isoxazolyl)penicillinsodium monohydrate (Prostaphlin), is the salt of a semisyntheticpenicillin that is highly resistant to inactivation bypenicillinase. Apparently, the steric effects of the 3-phenyland 5-methyl groups of the isoxazolyl ring prevent the bindingof this penicillin to the β-lactamase active site and,thereby, protect the lactam ring from degradation in muchthe same way as has been suggested for methicillin. It is alsorelatively resistant to acid hydrolysis and, therefore, may beadministered orally with good effect.
Oxacillin sodium, which is available in capsule form, isreasonably well absorbed from the gastrointestinal (GI)tract, particularly in fasting patients. Effective plasma levelsof oxacillin are obtained in about 1 hour, but despite extensiveplasma protein binding, it is excreted rapidly throughthe kidneys. Oxacillin experiences some first-pass metabolismin the liver to the 5-hydroxymethyl derivative. Thismetabolite has antibacterial activity comparable to that ofoxacillin but is less avidly protein bound and more rapidlyexcreted. The halogenated analogs cloxacillin, dicloxacillin,and floxacillin experience less 5-methyl hydroxylation.
The use of oxacillin and other isoxazolylpenicillinsshould be restricted to the treatment of infections causedby staphylococci resistant to penicillin G. Although theirspectrum of activity is similar to that of penicillin G, theisoxazolylpenicillins are, in general, inferior to it and thephenoxymethylpenicillins for the treatment of infectionscaused by penicillin G-sensitive bacteria. Because isoxazolylpenicillinscause allergic reactions similar to thoseproduced by other penicillins, they should be used withgreat caution in patients who are penicillin sensitive.
Purification Methods
This antibiotic, which is stable to penicillinase, is purified by recrystallisation from isoPrOH and dried in vacuo. Its solubility in H2O at 25o is 5%. [Doyle et al. Nature 192 1183 1961, Review: Chain et al. Antibiotics (Oxford University Press) 2 1949.]

OXACILLIN SODIUM 준비 용품 및 원자재

OXACILLIN SODIUM 공급 업체

OXACILLIN SODIUM 관련 검색

Send Inquriy