1-메틸-5-아미노-1H-벤즈이미다졸-2-부탄산에틸에스테르

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

• 예방조치문구

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

1-메틸-5-아미노-1H-벤즈이미다졸-2-부탄산에틸에스테르 화학적 특성, 용도, 생산

• 화학적 성질

  Brown Solid

• 용도

  1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester is a Bendamustine impurity.

• Synthesis

  In the hydrogenation reaction kettle by adding 50 g 1 - methyl -5 - nitro - 1H - benzimidazole -2 - butyric acid ethyl ester, 2.5 g 5% palladium/carbon, 1.3 L methanol, 475 ml ethyl acetate, hydrogen pressure control in the 0.1 - 0.2 mpa, reaction solution is 25 °C reaction 15 hours, TLC monitoring endpoint of the reaction to the reaction is complete. The fluid in a 35 °C decompression filter collects the filtrate; the filtrate is concentrated under reduced pressure to dry after adding 75 ml ethyl acetate, 70 °C stirring for 0.5 hours. After that, the mixture was to 5 °C stirring for 0.5 hours, for 5 °C standing crystallization for 2 hours, filtering, washing the filter cake with acetic acid ethyl ester, filtration cake at 50 °C decompression drying for 5 hours to afford 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 35 g, yield 77.8%.
  

1-메틸-5-아미노-1H-벤즈이미다졸-2-부탄산에틸에스테르 준비 용품 및 원자재

1-메틸-5-아미노-1H-벤즈이미다졸-2-부탄산에틸에스테르 공급 업체

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