Pitavastatin

한글명:Pitavastatin

카스 번호147511-69-1

상품명:Pitavastatin

CBNumberCB6206668

분자식C25H24FNO4

포뮬러 무게421.46

MOL 파일147511-69-1.mol

화학적 성질

녹는점	182 - 185°C
끓는 점	692.0±55.0 °C(Predicted)
밀도	1.352±0.06 g/cm3(Predicted)
저장 조건	-20°C, Hygroscopic
용해도	클로로포름(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)	4.24±0.10(Predicted)
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 황백색까지
안정성	흡습성
CAS 데이터베이스	147511-69-1(CAS DataBase Reference)
EPA	6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)- (147511-69-1)

위험 및 안전 성명

유해 물질 데이터

147511-69-1(Hazardous Substances Data)

그림문자(GHS)

Pitavastatin 화학적 특성, 용도, 생산

용도
HMGA reductase inhibitor
정의
ChEBI: A hydroxy monocarboxylic acid anion that is the conjugate base of pitavastatin, obtained by deprotonation of the carboxy group.
효소 저해제
This HMG-CoA reductase inhibitor (FW = 421.46 g/mol; CAS 147511-69- 1; IUPAC Name: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin- 3-yl]-3,5-dihydroxyhept-6-enoic acid), also known as itavastatin, itabavastin, nisvastatin, NK-104, NKS-104, and the trade name Livalo?, is indicated for ameliorating hypercholesterolemia and preventing cardiovascular disease. NK-104 potency is dose-dependent and is roughly equivalent to that of atorvastatin. It is well-tolerated in the treatment of patients with hypercholesterolemia. Pitavastatin uptake is carrier-mediated. Target(s): Reduces inflammatory cytokine production from human bronchial epithelial cells; Decreases microtubule tau protein levels via the inactivation of Rho/ROCK; Inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model; Suppresses therosclerosis induced by chronic inhibition of the synthesis of nitric oxide in moderately hypercholesterolemic rabbits; Decreases the expression of endothelial lipase both in vitro and in vivo; Inhibits NFkB pathway in brain; Inactivates NFkB and decreases IL-6 production through Rho kinase pathway in MCF-7 human breast cancer cells; Reduces C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells; Inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation; Inhibits upregulation of intermediate conductance calcium-activated potassium channels and coronary arteriolar remodeling induced by long-term blockade of nitric oxide synthesis; Inhibits migration and proliferation of rat vascular smooth muscle cells.

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