퀴놀린산
한글명:퀴놀린산
카스 번호89-00-9
상품명:Quinolinic acid
CBNumberCB7316162
분자식C7H5NO4
포뮬러 무게167.12
MOL 파일89-00-9.mol
동의어(한글)
2,3-피리딘디카르복시산
퀴놀린산
화학적 성질
| 녹는점 | 188-190 °C (dec.) (lit.) |
| 끓는 점 | 295.67°C (rough estimate) |
| 밀도 | 1.5216 (rough estimate) |
| 굴절률 | 1.6280 (estimate) |
| 저장 조건 | Keep in dark place,Sealed in dry,Room Temperature |
| 용해도 | 10g/L |
| 물리적 상태 | 결정성 분말 |
| 산도 계수 (pKa) | 2.43(at 25℃) |
| 색상 | 흰색에서 밝은 노란색-베이지색 |
| 냄새 | 냄새 없는 |
| 수용성 | 0.55g/100mL |
| Merck | 14,8073 |
| BRN | 137110 |
| InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
| CAS 데이터베이스 | 89-00-9(CAS DataBase Reference) |
| EPA | 2,3-Pyridinedicarboxylic acid (89-00-9) |
| 위험품 표기 | Xi | |||||||||
| 위험 카페고리 넘버 | 36/37/38-33 | |||||||||
| 안전지침서 | 26-36/37-24/25-37 | |||||||||
| WGK 독일 | 3 | |||||||||
| RTECS 번호 | US7967250 | |||||||||
| TSCA | T | |||||||||
| 위험 등급 | IRRITANT | |||||||||
| HS 번호 | 29333999 | |||||||||
| 유해 물질 데이터 | 89-00-9(Hazardous Substances Data) | |||||||||
| 독성 | Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur. | |||||||||
| NFPA 704: |
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