디펜히드라민

한글명:디펜히드라민

카스 번호58-73-1

상품명:Diphenhydramine

CBNumberCB6196202

분자식C17H21NO

포뮬러 무게255.35

MOL 파일58-73-1.mol

동의어(한글)

디펜히드라민

디펜히드라

다이펜하이드라민

화학적 성질

녹는점	167-172°C
끓는 점	bp2.0 150-165°
밀도	0.9889 (rough estimate)
굴절률	1.5450 to 1.5490
저장 조건	Keep in dark place,Inert atmosphere,Room temperature
용해도	클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태	기름
산도 계수 (pKa)	pKa 9.1 (Uncertain)
색상	오일과 같은 색상
Merck	14,3309
BCS Class	1
CAS 데이터베이스	58-73-1(CAS DataBase Reference)
NIST	Ethylamine, 2-diphenylmethoxy-n,n-dimethyl-(58-73-1)
EPA	Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl- (58-73-1)

위험 및 안전 성명

RTECS 번호

KR6825000

HS 번호

2922.19.7000

유해 물질 데이터

58-73-1(Hazardous Substances Data)

독성

LD50 oral in rat: 390mg/kg

NFPA 704:

	1
2		0

그림문자(GHS)

디펜히드라민 화학적 특성, 용도, 생산

개요
Diphenhydramine is one of the main representatives of antihistamine drugs that block H1 receptors. Besides antihistamine activity, diphenhydramine exhibits a local anesthetic effect, relaxes smooth muscle, and has sedative and soporific action.
용도
Diphenhydramine also reduces muscle rigidity and general stiffness, and has a relatively minor effect on tremors.
색상 색인 번호
This antihistaminic drug with sedative properties is mainly sold over the counter. It can be used both topically (treatment of pruritis) and orally for its antiallergic, antiemetic, sedative, and anticough properties. Allergic or photoallergic contact dermatitis and fixeddrug eruption seem to be rare.
Safety Profile
Deadly human poison by an unspecified route. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. Human systemic effects by ingestion: somnolence, alteration of operant conditioning, changes in psychophysiological tests. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO,. See also ETHERS.
환경귀착
Diphenhydramine is fairly stable in the environment although it does undergo photodegradation. Conjugates of diphenhydramine such as diphenhydramine-N-glucuronide may be converted back to the parent compound, diphenhydramine, through enzymatic cleavage during sewage treatment process. Diphenhydramine is removed poorly through wastewater treatment processes and is found in significant concentrations in aquatic organisms downstream from such plants.
Diphenhydramine has significant risk for bioaccumulation, particularly in water downstream from wastewater and sewage treatment facilities.
Solubility in water
One gram of diphenhydramine is soluble in 1 mL of water, 2 mL of ethanol, 2 mL of chloroform, or 50 mL of acetone; the compound is very slightly soluble in benzene or ether.

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