닐로티닙

한글명:닐로티닙

카스 번호641571-10-0

상품명:Nilotinib

CBNumberCB5966228

분자식C28H22F3N7O

포뮬러 무게529.52

MOL 파일641571-10-0.mol

동의어(한글)

닐로티닙

화학적 성질

녹는점	231-233 °C
밀도	1.36
저장 조건	-20°C Freezer
용해도	DMSO에 용해됨(최대 50mg/ml)
물리적 상태	베이지 파우더.
색상	회백색
안정성	제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
InChIKey	HHZIURLSWUIHRB-UHFFFAOYSA-N
SMILES	N1(C=C(C)N=C1)C1C=C(C=C(C=1)NC(=O)C1C=CC(C)=C(NC2=NC=CC(C3=CC=CN=C3)=N2)C=1)C(F)(F)F
CAS 데이터베이스	641571-10-0(CAS DataBase Reference)

위험 및 안전 성명

HS 번호	29335990
유해 물질 데이터	641571-10-0(Hazardous Substances Data)

그림문자(GHS)

닐로티닙 화학적 특성, 용도, 생산

개요
Chronic myeloid leukemia (CML), a hematological stem-cell disorder, is definitively diagnosed by the detection of the Philadelphia chromosome, a truncated version of chromosome 22 resulting from the reciprocal translocation of chromosomes 9 and 22 induced by a single mutagenic event. The consequence is the juxtaposition of two genes creating a fusion gene BCR-ABL. This gene leads to the translation of a fusion protein with increased tyrosine kinase activity that contributes to the pathogenesis of CML. Targeting the BCR-ABL protein has led to the successful intervention of the disease. Now established as first-line therapy for CML, imatinib was the first selective tyrosine kinase inhibitor of BCR-ABL. Since imatinib only binds to an inactive conformation of the ABL kinase portion, the conformational restrictions contribute to its selectivity.
화학적 성질
Off-White Solid
용도
Nilotinib, an orally active signal transduction inhibitor that selectively inhibits the tyrosine kinase Bcr-Abl, was discovered and developed by Norvartis and was launched for the treatment of chronic myeloid leukemia (CML) in patients with Philadelphia chromosome-positive (Ph+) disease who are resistant or intolerant to imatinib mesilate. Additional clinical trials are currently underway for the treatment of acute lymphoblastic leukemia (ALL) and gastrointestinal stromal tumors (GISTs).
정의
ChEBI: Nilotinib is a member of (trifluoromethyl)benzenes, a member of pyrimidines, a member of pyridines, a member of imidazoles, a secondary amino compound and a secondary carboxamide. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor and an anticoronaviral agent.
일반 설명
Class: non-receptor tyrosine kinase
Treatment: CML
Elimination half-life = 17 h
Protein binding >97.5%

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