Entacapone

한글명:Entacapone

카스 번호130929-57-6

상품명:Entacapone

CBNumberCB5726435

분자식C14H15N3O5

포뮬러 무게305.29

MOL 파일130929-57-6.mol

화학적 성질

녹는점	162-1630C
끓는 점	526.6±50.0 °C(Predicted)
밀도	1.392±0.06 g/cm3(Predicted)
저장 조건	2-8°C
용해도	DMSO: 용해성20mg/mL, 투명
물리적 상태	가루
산도 계수 (pKa)	pKa ~4.5(at 25℃)
색상	흰색에서 밝은 갈색까지
안정성	제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
InChIKey	JRURYQJSLYLRLN-BJMVGYQFSA-N
CAS 데이터베이스	130929-57-6(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

HS 번호

2926900005

유해 물질 데이터

130929-57-6(Hazardous Substances Data)

NFPA 704:

	0
3		0

그림문자(GHS)

Entacapone 화학적 특성, 용도, 생산

개요
Entacapone was introduced in Finland, Germany and Sweden as an adjunctive treatment with L-dopa in Parkinson’s disease. Entacapone is the second drug in its class to reach the market; it can be obtained by basecatalyzed condensation of the corresponding benzaldehyde with a cyanoacetamide. Entacapone is a highly selective and orally-active catechol-0- methyltransferase (COMT) inhibitor ; by inhibiting metabolism of L-dopa when given as an adjuvant in patients with Parkinson’s disease, Entacapone markedly prolongs the effects of L-dopa and improves its bioavailability. Results from clinical studies showed that 200mglday Entacapone coadministered with L-dopa lowered the dose of the latter required to reduce fluctuations in motor performance.
화학적 성질
Yellow Crystalline Solid
용도
(E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian
정의
ChEBI: A monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5 nitrophenyl group.
일반 설명
Entacapone, (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide (Comtan),is a nitrocatechol that is practically insoluble in water (pK_a＝4.50). Entacapone is rapidly absorbed after oral administrationand does not cross the BBB. Entacapone does not distributewidely into tissues because of its high plasma proteinbinding and it is completely metabolized before excretion.The main metabolic pathway is by isomerization to the cisisomerfollowed by direct glucuronidation of the parent andthe cis-isomer. The glucuronide conjugates are inactive.Entacapone is eliminated in the feces (90%) and urine (10%).Entacapone is indicated as an adjunct to levodopa/carbidopato treat patients with idiopathic PD who experience the signsand symptoms of end-of-dose wearing off.

Entacapone 준비 용품 및 원자재

Entacapone 공급 업체

Entacapone 관련 검색

Send Inquriy