피살라민

피살라민 화학적 특성, 용도, 생산

• 개요

  Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.

• 용도

  Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?

• 참고 문헌

  [1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
  [2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
  [3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
  [4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
  [5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457

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