머스크케톤

한글명:머스크케톤

카스 번호81-14-1

상품명:Musk ketone

CBNumberCB5458527

분자식C14H18N2O5

포뮬러 무게294.3

동의어(한글)

머스크케톤

화학적 성질

녹는점	134-137 °C
끓는 점	436.08°C (rough estimate)
밀도	1.2051 (rough estimate)
증기압	0.001Pa at 25℃
굴절률	1.5110 (estimate)
인화점	2 °C
저장 조건	2-8°C
용해도	DMSO : 250 mg/mL (849.47 mM; Need ultrasonic)
물리적 상태	Solid
색상	White to off-white
냄새	벤질 벤조에이트 중 10.00%. 지방 머스크 비눗물 건조 꽃 가루
?? ??	사향
수용성	불용성(20°C에서 <0.1g/100mL)
BRN	2062638
안정성	안정적인. 강한 산화제, 강산, 강염기와 호환되지 않습니다.
InChIKey	WXCMHFPAUCOJIG-UHFFFAOYSA-N
LogP	4.24 at 25℃
CAS 데이터베이스	81-14-1(CAS DataBase Reference)
NIST	2,6-Dimethyl-3,5-dinitro-4-t-butylacetophenone(81-14-1)
EPA	Musk ketone (81-14-1)

위험 및 안전 성명

위험품 표기	F,Xn,N
위험 카페고리 넘버	11-20/21/22-36-50/53-40
안전지침서	16-36/37-61-60-46
유엔번호(UN No.)	UN1648 3/PG 2
WGK 독일	2
RTECS 번호	KM5775841
HS 번호	2914790060
유해 물질 데이터	81-14-1(Hazardous Substances Data)
독성	Both the acute oral LD₅₀ in rats and the acute dermal LD₅₀ in rabbits exceeded 10 g/kg (Fogleman, 1970).

그림문자(GHS)

화학적 성질
It forms yellowish crystals with a sweet, very persistent, slightly animal musk odor.Musk ketone is prepared by Friedel–Crafts acetylation of 1,3-dimethyl-5-tert-butylbenzene and nitration of the resulting 2,6- dimethyl-4-tert-butylacetophenone with nitric acid.
Musk ketone is widely used as a fixative in blossom and fantasy compositions.
출처
Has apparently not been reported to occur in nature.
용도
Musk ketone is used as fragrance and fixative in after-shave lotions, perfumes, ete.
제조 방법
Nitration of the corresponding benzene derivative (Bedoukian, 1967).
일반 설명
Light yellow crystalline solid. Insoluble in water.
공기와 물의 반응
Insoluble in water.
반응 프로필
A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
화재위험
Flash point data is not available for Musk ketone, however, Musk ketone is probably combustible.
Purification Methods
Purify the ketone by recrystallisation from MeOH. It has a strong odour of musk and is used in perfumery. [Fuson et al. J Org Chem 12 587 1947, Beilstein 7 IV 808.]