4-(2-하이드록시에틸)-1-피페라진에탄술폰 산

한글명:4-(2-하이드록시에틸)-1-피페라진에탄술폰 산

카스 번호7365-45-9

상품명:HEPES

CBNumberCB5408557

분자식C8H18N2O4S

포뮬러 무게238.3

MOL 파일7365-45-9.mol

동의어(한글)

4-(2-하이드록시에틸)-1-피페라진에탄술폰산

4-(2-하이드록시에틸)-1-피페라진에탄술폰산(4-(2-HYDROXYETHYL)-1-PIPERAZINEETH...

하이드록시에틸피페라진에탄설포닉애씨드

화학적 성질

녹는점	234-238 °C
끓는 점	408℃[at 101 325 Pa]
벌크 밀도	560kg/m3
밀도	1.07 g/mL at 20 °C
증기압	0Pa at 25℃
굴절률	n20/D 1.339
저장 조건	2-8°C
용해도	H₂O: 1 M at 20 °C, 투명, 무색
물리적 상태	가루
색상	하얀색
수소이온지수(pH)	5.0-6.5 (1Maqueous solution)
산도 계수 (pKa)	7.5(at 25℃)
pH 범위	7.0 - 7.6
생물학적 소스	synthetic
수용성	녹는
최대 파장(λmax)	λ: 260 nm Amax: 0.06 λ: 280 nm Amax: 0.04
Merck	14,4654
BRN	883043
안정성	안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다. 습기로부터 보호하십시오.
주요 응용	진단 검사 제조
화장품 원료 기능	버퍼링
InChI	1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)
InChIKey	JKMHFZQWWAIEOD-UHFFFAOYSA-N
SMILES	OCCN1CCN(CC1)CCS(O)(=O)=O
LogP	-3.85 at 20℃
CAS 데이터베이스	7365-45-9(CAS DataBase Reference)
EPA	1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)- (7365-45-9)
Absorption	≤0.05 at 290 in H2O at 33%

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

24/25-22-36-26

WGK 독일

RTECS 번호

TL6809000

TSCA

TSCA listed

HS 번호

29335995

스토리지 클래스

13 - Non Combustible Solids

NFPA 704:

	1
2		1

그림문자(GHS)

4-(2-하이드록시에틸)-1-피페라진에탄술폰 산 MSDS

4-(2-하이드록시에틸)-1-피페라진에탄술폰 산 화학적 특성, 용도, 생산

개요
HEPES has been described as one of the best all-purpose buffers available for biological research. At biological pH, the molecule is zwitterionic, and is effective as a buffer at pH 6.8 to 8.2 (pKa 7.55). It is typically used in cell culture at concentration between 5mM to 30 mM. HEPES has been used in a wide variety of applications, including tissue culture. It is commonly used to buffer cell culture media in air. HEPES finds its usage in in vitro experiments on Mg.
화학적 성질
White crystalline powder
용도
Non-toxic to cell. It is used as a hydrogen ion buffer, which can control the constant pH range for long term. The concentration is 10-50mmol/L. Generally, 20mmol/LHEPES in nutrient solution can get buffer ability.
정의
ChEBI: A HEPES that is ethanesulfonate substituted by a 4-(2-hydroxyethyl)piperazin-4-ium-1-yl group at position 2.
일반 설명
HEPES buffered saline is a tissue culture buffer, which is used to maintain the pH of cell culture. It is water soluble and atmosphere independent. HEPES destroys magnesium in sodium chloride solutions.
생물학적 활성
HEPES is a multi purpose HEPES buffer used in cell culture and other biological research. Working pH range in aqueous solution: 6.8 - 8.2. Does not form complexes with metal ions. Used in cell culture media.
Biotechnological Applications
HEPES serves as a buffering agent and transfection reagent that mediates cytoplasmic delivery of proteins into cells, and mixing it with proteins such as antibodies, recombinant proteins, and small peptides yields protein–HEPES mixtures suitable for transfection into cultured cells[1]. As a zwitterionic buffering agent in cell culture media, HEPES activates MiT/TFE-dependent lysosomal-autophagic gene networks and induces lysosome biogenesis, while its addition to culture media also triggers a lysosomal stress-related inflammatory phenotype and affects host-immune gene programs in RAW macrophages[2]. HEPES serves as a building block for molecular engineering of biomedical polymers, functioning as a pendant group in the zwitterionic polymer polyHEPES-pz intended for biomedical applications[3].
Purification Methods
Crystallise the acid from hot EtOH and water. It is a useful buffer. [Beilstein 23 V 376.]

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