Verapamil

한글명:Verapamil

카스 번호52-53-9

상품명:Verapamil

CBNumberCB5376232

분자식C27H38N2O4

포뮬러 무게454.61

MOL 파일52-53-9.mol

화학적 성질

녹는점	25°C
끓는 점	243-246 °C (1.3 Pa)
밀도	1.1267 (rough estimate)
굴절률	1.5448
저장 조건	Keep in dark place,Inert atmosphere,Room temperature
용해도	DMSO: 100 mg/mL (219.97 mM)
물리적 상태	두꺼운 기름
산도 계수 (pKa)	8.6(at 25℃)
색상	무색
CAS 데이터베이스	52-53-9(CAS DataBase Reference)
NIST	Verapamil(52-53-9)
EPA	Verapamil (52-53-9)

위험 및 안전 성명

유해 물질 데이터	52-53-9(Hazardous Substances Data)
독성	LD50 oral in rat: 163mg/kg

그림문자(GHS)

Verapamil MSDS

Verapamil 화학적 특성, 용도, 생산

용도
Verapamil is primarily used as an antiarrythmic for treating ventricular arrhythmias; however, currently it is being forced out gradually by adenosine.
정의
ChEBI: A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
일반 설명
Verapamil, 5-[. Hemodynamically, verapamil causesa change in the preload, afterload, contractility, heart rate,and coronary blood flow. The drug reduces systemic vascularresistance and mean blood pressure, with minor effectson cardiac output.
Verapamil is a synthetic compound possessing slightstructural similarity to papaverine. It can be separated intoits optically active isomers, of which the levorotatory enantiomeris the most potent. It is absorbed rapidly after oraladministration. The drug is metabolized quickly and, as aresult, has low bioavailability. The liver is the main siteof first-pass metabolism, forming several products. Thepreferential metabolic step involves N-dealkylation, followedby O-demethylation, and subsequent conjugation ofthe product before elimination. The metabolites have no significantbiological activity. Verapamil has an eliminationhalf-life of approximately 5 hours.
Mechanism of action
Verapamil is used as an antiarrythmic drug in treating supraventricular arrythmia such as paroxysmal atrial tachycardia, and for controlling atrial fibrillation. By blocking entrance of Ca2+ in the cell, verapamil exhibits a negative inotropic effect, and therefore it cannot be combined with β-adrenoblockers or cynidine since that would lead to an increased inotropic effect.
Clinical Use
Verapamil (Isoptin, Covera), in addition to its use as an antiarrhythmic agent, has been employed extensively in the management of variant (Prinzmetal’s) angina and effort-induced angina pectoris. It selectively inhibits the voltage-gated calcium channel that is vital for action potential genesis in slowresponse myocytes, such as those found in the sinoatrial and A-V nodes.
Verapamil is useful for slowing the ventricular response to atrial tachyarrhythmias, such as atrial flutter and fibrillation. Verapamil is also effective in arrhythmias supported by enhanced automaticity, such as ectopic atrial tachycardia and idiopathic left ventricular tachycardia.
부작용
Orally administered verapamil is well tolerated by most patients. Most complaints are of constipation and gastric discomfort. Other complaints include vertigo, headache, nervousness, and pruritus.
주의 사항
Verapamil must be used with extreme caution or not at all in patients who are receiving -adrenoceptor blocking agents. Normally, the negative chronotropic effect of verapamil will in part be overcome by an increase in reflex sympathetic tone. The latter is be prevented by simultaneous administration of a β-adrenoceptor blocking agent, which exaggerates the depressant effects of verapamil on heart rate, A-V node conduction, and myocardial contractility. The use of verapamil in children less than 1 year of age is controversial.

Verapamil 준비 용품 및 원자재

Verapamil 공급 업체

Verapamil 관련 검색

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