2-Bromo-3-fluoro-6-picoline

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H312：피부와 접촉하면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H332：흡입하면 유해함

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P304+P340：흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P405：밀봉하여 저장하시오.

2-Bromo-3-fluoro-6-picoline 화학적 특성, 용도, 생산

• Synthesis

  3-Amino-2-bromo-6-methylpyridine or 4-amino-2-bromo-6-methylpyridine (25.20 g, 134.73 mmol) was added to a mixture of water (78.1 mL) and conc. HCl (12.8 mL, 350.30 mmol), and then the mixture was cooled to 0 ℃. To it, sodium nitrite (18.6 g,269.46 mmol) was added portion-wise with stirring over 20 min while keeping the reaction temperature between –5 ℃and 0 ℃. After 10 min, 65 per cent hexafluorophosphoric acid solution (43.26 g, 296.41 mmol) was added dropwise with cooling, at which point many precipitates were formed. The precipitates were collected by filtration using a glass filter funnel, washed with cold water (2 × 50 mL) and diethyl ether (100 mL), and then dried in the air for 48 h. The solid was slowly heated to 100 ℃ (very exothermic), and a dark, oily material was formed after 10 min. The oil was basified with diluted NaOH solution to pH~10 and extracted with CH2Cl2 (2 × 150 mL). The combined organic layer was dried over anhydrous Na2SO4, filtered, and evaporated to dryness under reduced pressure. The residue was purified by MPLC on neutral alumina using hexane/EtOAc (10:1) as an eluent to afford 2-Bromo-3-fluoro-6-picoline.

2-Bromo-3-fluoro-6-picoline 준비 용품 및 원자재

2-Bromo-3-fluoro-6-picoline 공급 업체

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