Nisoldipine

한글명:Nisoldipine

카스 번호63675-72-9

상품명:Nisoldipine

CBNumberCB5147166

분자식C20H24N2O6

포뮬러 무게388.41

MOL 파일63675-72-9.mol

화학적 성질

녹는점	147-148°C
끓는 점	503.3±50.0 °C(Predicted)
밀도	1.205±0.06 g/cm3(Predicted)
저장 조건	room temp
용해도	DMSO: >10mg/mL
산도 계수 (pKa)	2.67±0.70(Predicted)
물리적 상태	가루
색상	노란색
Merck	14,6565
InChIKey	VKQFCGNPDRICFG-UHFFFAOYSA-N
CAS 데이터베이스	63675-72-9(CAS DataBase Reference)
NIST	Nisoldipine(63675-72-9)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

20/21/22

안전지침서

WGK 독일

RTECS 번호

US7975600

HS 번호

2933399090

NFPA 704:

	0
3		0

그림문자(GHS)

Nisoldipine 화학적 특성, 용도, 생산

개요
Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.
화학적 성질
Nisoldipine D4 is Light Tan Crystals
용도
Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.
정의
ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.
일반 설명
In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.

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