아크로시노나이드

아크로시노나이드 화학적 특성, 용도, 생산

• Originator

  Acrocinonide ,Onbio Inc.

• Manufacturing Process

  A suspension of 1.0 g of 9-fluoro-11β,16α,17,21-tetra-hydroxy-pregna-1,4- diene-3,20-dione in a mixture of 35 ml of dioxan, 15 ml of acrolein and 0.1 ml of perchloric acid was stirred for 3 h at room temperature. The clear solution thus obtained was poured into an aqueous saturated solution of sodium bicarbonate. The mixture was extracted twice with benzene, and the benzenic extract was concentrated to a small volume. The resulting crystals were collected and the 9-fluoro-11β,21-dihydroxy-16α,17-(2-propenylidenedioxy)- pregna-1,4-diene-3,20-dione was obtained as white crystals, melting point 200°-205°C.

• Therapeutic Function

  Antiinflammatory, Antiallergic

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