S-ADENOSYL-L-METHIONINE CHLORIDE SALT

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

S-ADENOSYL-L-METHIONINE CHLORIDE SALT 화학적 특성, 용도, 생산

• Purification Methods

  Purify it by ion exchange on Amberlite IRC-150 and eluting with 0.1-4M HCl. [Stolowitz & Minch J Am Chem Soc 103 6015 1981.] It has been isolated as the tri-reineckate salt by adding 2volumes of 1% solution of ammonium reineckate in 2% perchloric acid. The reineckate salt separates at once but is kept at 2o overnight. The salt is collected on a sintered glass funnel, washed with 0.5% of ammonium reineckate, dried (all operations at 2o) and stored at 2o. To obtain adenosylmethionine, the reineckate is dissolved in a small volume of methyl ethyl ketone (MEK) and centrifuged at room temperature to remove a small amount of solid. The clear dark red supernatant is extracted (in a separating funnel) with a slight excess of 0.1N H2SO4. The aqueous phase is re-extracted with fresh MEK until it is colourless. [Note that reineckates have UV absorption at 305nm ( 15,000), and the optical density at 305nm is used to detect and estimate reineckate ions.] MEK is removed from the aqueous layer containing adenosylmethionine sulfate; the pH is adjusted to 5.6-6.0 and extracted with two volumes of Et2O. The sulfate is obtained by evaporating the aqueous layer in vacuo. The hydrochloride can be obtained in the same way but using HCl instead of H2SO4. SAM-HCl has a solubility of 10% in H2O. The salts are stable in the cold at pH 4-6 but decompose in alkaline media. [Cantoni Biochemical Preparations 5 58 1957.] The purity of SAM can be determined by paper chromatography [Cantoni J Biol Chem 204 403 1953, Methods Enzymol 3 601 1957], electrophoretic methods or enzymic analysis [Cantoni & Vignos J Biol Chem 209 647 1954]. [Beilstein 26 III/IV 3676.]

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