Endothelin-1 (human, porcine)

한글명:Endothelin-1 (human, porcine)

카스 번호117399-94-7

상품명:Endothelin-1 (human, porcine)

CBNumberCB4706533

분자식C109H159N25O32S5

포뮬러 무게2491.9

MOL 파일117399-94-7.mol

화학적 성질

끓는 점	2467.3±65.0 °C(Predicted)
밀도	1.273±0.06 g/cm3(Predicted)
저장 조건	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
용해도	1% 아세트산: >1mg/mL
물리적 상태	가루
색상	하얀색
수용성	물에 용해됩니다.
Merck	13,3610
InChIKey	ZUBDGKVDJUIMQQ-UHFFFAOYSA-N

위험 및 안전 성명

WGK 독일	3
RTECS 번호	KE9446500
F 고인화성물질	3-10
HS 번호	2937190000

그림문자(GHS)

Endothelin-1 (human, porcine) 화학적 특성, 용도, 생산

용도
Endothelin-1 (human, porcine) has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
주요 응용
Endothelin-1 (human, porcine) has been used:
to study its effects on the production of erythropoietin under normoxia and carbon monoxide-induced hypoxia in rat models.
as a protein kinase C (PKC) agonist to study its effects on the phosphorylation of myofilament proteins in rat myocytes.
to induce a hypertrophic-like state to study its effects on contraction pressure in normal and mutated human induced pluripotent stem cells (hiPSC)-derived cardiomyocytes.
in vitro hydrolysis products of macroendothelin-1, a precursor of endothelin-1, and their pharmacodynamic properties in rabbits.
as a receptor for endothelin-1 and its role in G protein-mediated signal transduction Research.
Biological Functions
Endothelins are a family of vasoactive peptides secreted by endothelial cells. The three major endothelin peptides are all composed of 21 amino acids. Endothelins are the most potent vasoconstrictors known. Contraction of vascular smooth muscle in response to endothelin is associated with an increase in intracellular calcium. Increases in endothelin levels have been reported in patients with vasospastic, hypoxic, and ischemic diseases.The two identified isoforms of endothelin receptors have differing affinity for the three endothelin peptides. Selective and nonselective endothelin receptor antagonists are in development for potential use in the treatment of hypertension and other disorders associated with increased vascular resistance.
Biochem/physiol Actions
Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.

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