4-Epioxytetracycline

한글명:4-Epioxytetracycline

카스 번호14206-58-7

상품명:4-Epioxytetracycline

CBNumberCB4500795

분자식C22H24N2O9

포뮬러 무게460.43

MOL 파일14206-58-7.mol

화학적 성질

녹는점	168°C
끓는 점	839.6±65.0 °C(Predicted)
밀도	1.71±0.1 g/cm3(Predicted)
저장 조건	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
용해도	DMSO: slightly soluble; Methanol: slightly, heated
물리적 상태	가루
산도 계수 (pKa)	4.50±1.00(Predicted)
색상	녹색빛이 도는 베이지색에서 갈색을 띤다
안정성	Hygroscopic, Light Sensitive, Unstable in Solution
EPA	2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4R,4aR,5S,5aR,6S,12aS)- (14206-58-7)

위험 및 안전 성명

HS 번호

29413020

NFPA 704:

	0
2		0

그림문자(GHS)

4-Epioxytetracycline 화학적 특성, 용도, 생산

개요
Epioxytetracycline is a metabolite of Oxytetracycline. It has been found in swine manure compost and wastewater and is considered a pollutant. This highly pure metabolite can be used as a secondary reference standard during stability studies of oxytetracycline. It can also be used to study the degradation pathway and products of tetracyclines.
화학적 성질
greenish-beige to brownish powder
Mode of action
Oxytetracycline causes inhibition of protein synthesis. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome.
In an acellular model system of protein synthesis using ribosomes from tetracycline-sensitive and resistant strains of E. coli in the synthesis of polyphenylalanine, Oxytetracycline showed inhibitory activity along with minocycline. 4-Epioxytetracycline and beta-apo-oxytetracycline had competing properties with respect to oxytetracycline at the stage of penetration through the cell membrane but did not, however, suppress the synthesis of polyphenylalanine.
참고 문헌
1] I V BELIAVSKAIA. [Study of the mechanism of action of minocycline and of certain other tetracycline group compounds].[J]. Antibiotiki, 1976, 21 3: 242-245.
[2] BENT HALLING-S?RENSEN J. T G Sengel?v. Toxicity of Tetracyclines and Tetracycline Degradation Products to Environmentally Relevant Bacteria, Including Selected Tetracycline-Resistant Bacteria[J]. Archives of Environmental Contamination and Toxicology, 2002, 42 1: 263-271. DOI:10.1007/s00244-001-0017-2.
[3] ANNE KRUSE LYKKEBERG . Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS[J]. Journal of pharmaceutical and biomedical analysis, 2004, 34 2: Pages 325-332. DOI:10.1016/S0731-7085(03)00500-4.
[4] RICHENG XUAN. Hydrolysis and photolysis of oxytetracycline in aqueous solution.[J]. Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes, 2010, 45 1: 73-81. DOI:10.1080/03601230903404556.
[5] HONGXING HAN. Impact of 4-epi-oxytetracycline on the gut microbiota and blood metabolomics of Wistar rats[J]. Scientific Reports, 2016, 6 1. DOI:10.1038/srep23141.

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