6-Nitroveratraldehyde

한글명:6-Nitroveratraldehyde

카스 번호20357-25-9

상품명:6-Nitroveratraldehyde

CBNumberCB4275729

분자식C9H9NO5

포뮬러 무게211.17

MOL 파일20357-25-9.mol

화학적 성질

녹는점	131-133 °C (lit.)
끓는 점	350.84°C (rough estimate)
밀도	1.4194 (rough estimate)
굴절률	1.5700 (estimate)
저장 조건	Keep in dark place,Sealed in dry,Room Temperature
용해도	DMSO: 22mg/mL
물리적 상태	고체
물리적 상태	단단한 모양
색상	노란색
수용성	물에 불용성. 부드럽게 가열하면 에탄올에 25mM, DMSO에 100mM까지 용해됩니다.
감도	Air & Light Sensitive
BRN	395599
CAS 데이터베이스	20357-25-9(CAS DataBase Reference)
NIST	6-Nitroveratraldehyde(20357-25-9)

위험 및 안전 성명

위험품 표기

안전지침서

24/25

WGK 독일

RTECS 번호

GY8410000

위험 등급

IRRITANT

HS 번호

29130000

NFPA 704:

	1
0		0

그림문자(GHS)

6-Nitroveratraldehyde MSDS

6-Nitroveratraldehyde 화학적 특성, 용도, 생산

화학적 성질
yellow fluffy powder
용도
6-Nitroveratraldehyde has been used in the preparation of no-carrier-added 6-18F-fluoro-L-dopa, fundamental tracer for cerebral positron emission tomography studies of dopaminergic system in humans and o-nitroaryl-bis(5-methylfur-2-yl)methanes, versatile synthons for the synthesis of nitrogen-containing heterocycles. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair. It is also used for synthesizing analogs of alpha-asarone.
일반 설명
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC₅₀ = 15 μM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.
생물학적 활성
Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC 50 = 15 μ M), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.
Purification Methods
The aldehyde is purified by dissolving 9g in 200mL of boiling 95% EtOH, and set aside overnight to crystallise. It is then dried in vacuo at 50o and recrystallised from 110mL of 95% EtOH to give 6-7g of aldehyde with m 132-133o. Crystallisation from aqueous EtOH provides light yellow needles. It is light sensitive and should be stored in the dark [Fetscher Org Synth Coll Vol 4 735 1963]. [Beilstein 8 H 262, 8 I 610, 8 II 290, 6 III 2065, 6 IV 1785.]

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