Pemetrexed

한글명:Pemetrexed

카스 번호137281-23-3

상품명:Pemetrexed

CBNumberCB4170583

분자식C20H21N5O6

포뮬러 무게427.41

MOL 파일137281-23-3.mol

화학적 성질

밀도	1.59±0.1 g/cm3(Predicted)
저장 조건	2-8°C(protect from light)
용해도	slightly sol. in Methanol
물리적 상태	powder to crystal
산도 계수 (pKa)	3.58±0.10(Predicted)
색상	White to Blue
Merck	14,7077
CAS 데이터베이스	137281-23-3(CAS DataBase Reference)

위험 및 안전 성명

RTECS 번호	LZ9950100
HS 번호	2933.99.9701
유해 물질 데이터	137281-23-3(Hazardous Substances Data)

그림문자(GHS)

Pemetrexed 화학적 특성, 용도, 생산

화학적 성질
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt is Off-White Solid
용도
Pemetrexed is used in the treatment of malignant pleural mesothelioma (MPM) and erectile dysfunction therapy.
정의
ChEBI: Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antineoplastic agent, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a pyrrolopyrimidine and a N-acyl-L-glutamic acid. It is a conjugate acid of a pemetrexed(2-).
부작용
The most common side effects for pemetrexed include fatigue, nausea, vomiting, anorexia, mucositis, myelosuppression ± infection, bleeding, rash, diarrhea and ↑ LFTs.
Severe myelosuppression is often dose-limiting for pemetrexed. Sepsis, in some cases fatal, have occurred in approximately 1% of patients in clinical trials. Prophylactic folic acid and intramuscular vitamin B12 supplements are necessary to reduce hematologic or non-hematologic toxicities.
Pemetrexed may cause serious and in some cases fatal dermatologic toxicities. Rarely, StevensJohnson syndrome and toxic epidermal necrolysis have been reported.
Mode of action
Pemetrexed is a pyrrolopyrimidine antifolate that exerts its antineoplastic activity by inhibiting thymidylate synthase (TS), glycinamide ribonucleotide formyltransferase (GARFT) and dihydrofolate reductase (DHFR), which are involved in folate metabolism and DNA synthesis, resulting in inhibition of purine and thymidine nucleotide synthesis.

Pemetrexed 공급 업체

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