마약

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H301：삼키면 유독함

마약 화학적 특성, 용도, 생산

• 개요

  Narciclasine is a plant growth inhibitor that can be isolated from Narcissus bulbs. At 1 μM, it has been shown to induce apoptosis-mediated cytotoxicity in human cancer cells in vitro but not in normal fibroblasts. Narciclasine has been shown to regulate the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner.

• 용도

  Narciclasine is reasonably abundant in some Narcissus spp. and has served as a very useful intermediate for synthetic conversion into (+)-pancratistatin and to conduct a series of structure–activity relationship studies . Bicolorine, another member of the narciclasine series, is an unusual, completely aromatized quaternary alkaloid with an N-methyl group.

• 정의

  ChEBI: A natural product found in Narcissus pseudonarcissus.

• 참고 문헌

  Ceriotti., Nature, 213,595 (1967)
  Piozzi et al., Tetrahedron, 24, 1119 (1968)
  Revised structure: Mondon, Krohn., Tetrahedron Lett., 2123 (1970)
  Savona, Piozzi, Marino., Chern. Cornrnun., 1006 (1970)
  Absolute configuration: Fuganti, Mazza.,J. Chern. Soc., Chern. Cornrnun., 239 (1972)
  Crystal structure: Immirzi, Fuganti., J. Chern. Soc., Chern. Cornrnun., 240 (1972)
  Stereochemistry: Mondon, Krohn., Tetrahedron Lett., 2085 (1972)

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