MURISTERONE A

MURISTERONE A 화학적 특성, 용도, 생산

• 개요

  Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (K_d = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.

• 용도

  Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells.

• 생물학적 활성

  Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

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