데스로라타딘

한글명:데스로라타딘

카스 번호100643-71-8

상품명:Desloratadine

CBNumberCB3462564

분자식C19H19ClN2

포뮬러 무게310.82

MOL 파일100643-71-8.mol

동의어(한글)

데스로라타딘

화학적 성질

녹는점	150-151°C
끓는 점	467.9±45.0 °C(Predicted)
밀도	1?+-.0.06 g/cm3(Predicted)
저장 조건	2-8°C
용해도	DMSO: >10mg/mL
산도 계수 (pKa)	10.27±0.20(Predicted)
물리적 상태	가루
색상	White to Light orange to Yellow
Merck	14,2922
BCS Class	1
InChIKey	JAUOIFJMECXRGI-UHFFFAOYSA-N
CAS 데이터베이스	100643-71-8(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

RTECS 번호

DE8011000

HS 번호

2933399090

NFPA 704:

	0
3		0

그림문자(GHS)

그림문자(GHS)
신호 어

Danger
유해·위험 문구

H302：삼키면 유해함

H318：눈에 심한 손상을 일으킴

H361：태아 또는 생식능력에 손상을 일으킬 것으로 의심됨

H411：장기적 영향에 의해 수생생물에 유독함
예방조치문구

P201：사용 전 취급 설명서를 확보하시오.

P202：모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.

P264：취급 후에는 손을 철저히 씻으시오.

P264：취급 후에는 손을 철저히 씻으시오.

P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

P281：요구되는 개인 보호구를 착용하시오

P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

P308+P313：노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.

P310：즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.

P330：입을 씻어내시오.

P405：밀봉하여 저장하시오.

P501：...에 내용물 / 용기를 폐기 하시오.

데스로라타딘 화학적 특성, 용도, 생산

개요
Desloratadine is a second generation of tricyclic antihistamine. It is a H1-receptor antagonist which has anti-inflammatory activity. Its affinity to the H1 receptor is higher than most other H1-receptor antagonists. Desloratadine works by blocking a certain natural substance (histamine) which is produced during an allergic reaction. Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Desloratadine is used to treat nasal and non-nasal symptoms (watery eyes, runny nose, itching eyes/nose, sneezing, and itching) of seasonal allergic rhinitis. It is also used to relieve chronic itching caused by hives.
화학적 성질
Beige Solid
용도
Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.
정의
ChEBI: Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis nd chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.
Indications
Desloratadine (Clarinex) is an active metabolite of loratadine. A 5 mg daily dose has been shown to be effective. There is no evidence that it offers any advantage over loratadine. Fexofenadine (like its parent compound terfenadine) may rarely promote cardiac arrhythmias (24). No significant difference in efficacy has been noted in the nonsedating H1 blockers. Combinations of nonsedating antihistamines in the morning and sedating antihistamines in the evening may be more cost effective than increasing doses of the nonsedating agent.
일반 설명
Desloratadine, 8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine(Clarinex) is a white to off-white powder that is slightlysoluble in water, but very soluble in ethanol and propyleneglycol. It is the proposed active metabolite loratadine and hasa very similar receptor binding and safety profile. It is indicated for the symptomatic relief of pruritus andreduction in the number and size of hives in chronic idiopathicurticaria patients 6 months of age and older and for therelief of the nasal and nonnasal symptoms of perennial allergicrhinitis (in patients 6 months of age and older) and seasonalallergic rhinitis (in patients 2 years of age and older).
Desloratadine is extensively metabolized to 3-hydroxydesloratadine,also an active metabolite, which is subsequentlyglucuronidated . The cytochrome enzymesresponsible for the formation of 3-hydroxydesloratadinehave not been reported. Coadministration ofdesloratadine with CYP3A4 inhibitors results in marginalincreases in plasma concentrations of desloratadine and3-hydroxydesloratadine, but no significant changes in safetyor efficacy. The mean elimination half-life of desloratadineis about 6 hours, and the drug and its metabolites areeliminated in the urine and feces.
참고 문헌
[1] https://www.drugbank.ca
[2] Raif S. Geha, Eli O. Meltzer (2001) Desloratadine: A new, nonsedating, oral antihistamine, The Journal of Allergy and Clinical Immunology,107, 751-762

데스로라타딘 준비 용품 및 원자재

데스로라타딘 공급 업체

데스로라타딘 관련 검색

Send Inquriy