Cetirizine

한글명:Cetirizine

카스 번호83881-51-0

상품명:Cetirizine

CBNumberCB3440625

분자식C21H25ClN2O3

포뮬러 무게388.89

MOL 파일83881-51-0.mol

화학적 성질

녹는점	110-115°C
끓는 점	542.1±45.0 °C(Predicted)
밀도	1.237±0.06 g/cm3(Predicted)
저장 조건	2-8°C
용해도	insoluble in EtOH; ≥122 mg/mL in H2O; ≥19.44 mg/mL in DMSO
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	3.46±0.10(Predicted)
색상	Off-white to light yellow
수용성	101mg/L
CAS 데이터베이스	83881-51-0(CAS DataBase Reference)
EPA	Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- (83881-51-0)

위험 및 안전 성명

WGK 독일	3
RTECS 번호	AG0977500
유해 물질 데이터	83881-51-0(Hazardous Substances Data)

그림문자(GHS)

Cetirizine 화학적 특성, 용도, 생산

화학적 성질
white, crystalline powder
용도
Cetirizine is a metabolite of the first-generation H1 antihistamine hydroxyzine. A reduced dosage (5 mg daily) is recommended in patients with chronic renal or hepatic impairment. Sedative side effects increase with dosages of cetirizine >10 mg per day.
정의
ChEBI: A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
일반 설명
Cetirizine, (±)-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetic acid (Zyrtec), is a racemic compound available as a white crystalline powder that is water soluble. Cetirizine is the primary acid metabolite of hydroxyzine, resulting from complete oxidation of the primary alcohol moiety. This compound is zwitterionic and relatively polar and thus does not penetrate or accumulate in the CNS. Before its introduction in the United States, cetirizine was one of the most widely prescribed H1-antihistamines in Europe.
Cetirizine is indicated for the temporary relief of runny nose, sneezing, itching of the nose or throat, and/or itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also relieves itching caused by hives (urticaria), but it will not prevent hives or an allergic skin reaction from occurring.
Clinical Use
Cetirizine, the acid metabolite from oxidation of the primary alcohol of the antihistamine hydroxyzine, is a widely used antihistamine. It has a long duration of action and is highly selective for H1 receptors. No cardiotoxicity has been reported, but some drowsiness occurs.

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