1,3-비스(2,6-디이소프로필페닐)이미다졸륨클로라이드

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P271：옥외 또는 환기가 잘 되는 곳에서만 취급하시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

1,3-비스(2,6-디이소프로필페닐)이미다졸륨클로라이드 화학적 특성, 용도, 생산

• 화학적 성질

  White to Light yellow to Light orange powder to crystal. soluble in methanol.

• 용도

  1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is also used in organic synthesis, as well as a pharmaceutical intermediate. 1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is used as a reagent in the synthesis of NHC Copper(I) complexes bearing dipyridylamine ligands which exhibit interesting luminescent properties and are potential candidates for organic light-emitting diode applications. 1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is also used as a reagent in the synthesis of 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic Acid Methyl Ester (D476595); the methyl ester derivative of the drug Vadimezan (V084950).

• 주요 응용

  1,3-Bis(2,6-Diisopropylphenyl)imidazolium chloride is also used as a reagent in the synthesis of 5,6-Dimethyl-9-Oxo-9H-xanthene-4-acetic acid methyl ester; the methyl ester derivative of the drug Vadimezan. Moreover, it is an imidazolium salt that is active against all stages of Trypanosoma Cruzi and may represent a promising candidate for treatment of Chagas disease.

• 화학 반응

  Precursor to Pd catalysts used in C-N and C-C coupling reactions.
  Ligand used in double carbonylation reactions.
  Precursor to Ni catalysts used in C-N coupling reactions.
  Precursor to Cu catalysts used in copper hydride reactions.
  Ligand used in Ru-catalyzed carbonylative C-H cyclization of 2-aryl phenols.
  

• Safety

  H300 (37.84%): Fatal if swallowed [Danger Acute toxicity, oral]
  H315 (62.16%): Causes skin irritation [Warning Skin corrosion/irritation]
  H317 (37.84%): May cause an allergic skin reaction [Warning Sensitization, Skin]
  H318 (37.84%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  H319 (62.16%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
  H400 (37.84%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
  H410 (37.84%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

• 참고 문헌

  Suzuki-Miyaura Reaction
  Esterification of α-Halo-α,β-unsaturated Aldehydes by Using a Carbene Catalyst
  Cycloaddition of CO2 to Epoxides Catalyzed by N-Heterocyclic Carbene (NHC)–ZnBr2 System under Mild Conditions
  
  [1] Yan C, et al. An efficient and recyclable iron(III)-containing imidazolium salt catalyst for cross-coupling of aryl Grignard reagents with alkyl halides. Science Bulletin, 2012; 57: 1953–1958.
  [2] Hans M, et al. Efficient synthetic protocols for the preparation of common N-heterocyclic carbene precursors. Beilstein Journal of Organic Chemistry, 2015; 11: 2318–2325.

1,3-비스(2,6-디이소프로필페닐)이미다졸륨클로라이드 공급 업체

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